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Predictors of Sustained Virologic Response Among Poor Interferon Responders When Boceprevir is Added to Peginterferon alfa-2b/Ribavirin
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Reported by Jules Levin
AASLD Nov 5-8 2011 SF
B. Bacon1, S. Bruno2, E. Schiff 3, P. Kwo4, M. Buti5, L. Pedicone6, W. Deng6, M. Burroughs6, C. Brass6, J. Albrecht6, S. Flamm7
1Saint Louis University School of Medicine, St. Louis, MO, 2A.O. Fatebenefratelli e Oftalmico, Milan, Italy, 3University of Miami, Miami, FL, 4Indiana University School of Medicine, Indianapolis, IN, 5Vall d'Hebron University Hospital, Barcelona, Spain, 6Merck, Sharp & Dohme Corp., Whitehouse Station, NJ, 2Northwestern Feinberg School of Medicine, Chicago, IL
from Jules: week 4 response to lead-in with peg/rbv is a good predictor of SVR, but SVR predictors for poor interferon responders are: being genotype 1b compared to 1a, having less fibrosis (F0/1/2 compared to F3), having a baseline viral load of <3 IU/mL, and no patient with <3 log decline in viral load at treatment week 8 achieved SVR
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