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Recombinant Interleukin-7 (CYT107) Expands CD4 T Cells in Peripheral Blood and Gut Mucosa of Chronically HIV-Infected Immunological Non-Responder Patients
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Reported by Jules Levin
CROI 2011 Feb 27-March 2 Boston
Irini Sereti1, Jean-Pierre Routy2, Margaret Fischl3, Thˇr¸se Croughs4, Stˇphanie Beq4, Michel Morre4, Mohamed R Boulassel2, Michael Yao1, William Thompson1, Michael M Lederman5.
1. NIAID NIH, Bethesda, MD USA; 2. McGill University, Montreal, QC, Canada; 3.University of Miami, Miami, FL USA; 4. Cytheris, Paris, France; 5. Case Western Reserve University, Cleveland , OH, USA
10 Center Drive,
Bldg 10/11B07A
Bethesda, MD 20892
isereti@niaid.nih.gov
P: 301-496-5533
Link to Abstract & Summary-
CROI: Recombinant IL-7 Expands CD4 T Cells in Peripheral Blood and Gut Mucosa of Chronically HIV-infected Immunological Non-responder Patients (03/11/11)
"Median CD4 and CD8 T cells counts were 272 and 554 cells/mm3 at baseline, increasing to 652 and 986 cells/mm3 at week 12, respectively.....Mucosal gut biopsy analysis showed an increase in both CD4 T cell frequency (38.85 ± 9.07 pre vs 53.08 ± 11.52 post p = 0.0273) and counts (106/gr tissue: 2.29 ± 1.15 pre vs 9.01 ± 7.85 post p = 0.1709).....CD4 T-cell depletion in gut mucosa is an early and key pathogenic event in HIV infection that is associated with T cell activation.........These data suggest that CYT107 administration can significantly expand CD4 and CD8 T cells with lower expression of PD-1 while increasing the expression of gut homing molecules that may result in the restoration of the CD4 population of the gut mucosa......the results demonstrate the importance of IL-7 in stimulating T-cell repopulation of the lymphoid tissue layer in the mucous membrane of the GI tract. This effect, previously demonstrated in SIV infected monkeys, is now confirmed by analysis of rectosigmoid biopsies in this study of HIV infected patients defined as Immunological Non-Responders (INR)."
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