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Screening for Cognitive Impairment in Human Immunodeficiency Virus
 
 
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CID Oct 15 2011
 
"Overall, there are important considerations for early detection of cognitive impairment, particularly among older HIV-positive patients. Unlike the general healthy population, older HIV-positive patients are managing a complex medical condition that disrupts CNS integrity and cognitive function and may be life threatening if not adequately controlled through medical intervention. With HIV, treatment failure and broad antiretroviral medication resistance are potential outcomes of cognitive impairment. As such, unlike in the healthy older population, failure to identify cognitive deficits in the HIV-positive population may directly influence successful management of the disease. In balance, there are important clinical needs that can be addressed by research aimed at demonstrating whether improved detection results in improved outcomes. ....
 
At this point, only general recommendations can be made regarding appropriate screening tools for HAND. Both HIV and cerebrovascular disease-specific pathology would be expected to demonstrate preferential subcortical involvement, thereby negating the utility of screening measures that do not adequately tap cognitive domains and effectively excluding use of the MMSE as a screening tool. Currently available HIV-targeted screening instruments, such as the HDS, have marked limitations in that they are sensitive only for the most severe forms of impairment."

 
Victor Valcour,1,2 Robert Paul,3 Stephanie Chiao,1 Lauren A. Wendelken,1 and Bruce Miller1 1Memory and Aging Center, Department of Neurology, 2Division of Geriatric Medicine, Department of Medicine, University of California-San Francisco; and 3Department of Psychology, Division of Neuroscience, University of Missouri, St. Louis
 
Abstract
 
Recent publications estimate the prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) exceeds 50%, and this rate is likely higher among older patients. Cognitive impairment may impact medication adherence, and symptomatic impairment has been linked to all-cause mortality providing some impetus for early detection. There are currently insufficient data to inform solid recommendations on screening methods. Most HIV-specific tools have poor performance characteristics for all but the most severe form of impairment, which accounts for <5% of cases. Reliance on symptoms is likely to miss a substantial proportion of individuals with HAND due to poor insight, confounding mood disturbances, and lack of well-informed proxies. In the aging HIV-positive population, broader screening tools may be required to allow sensitivity for both HIV and neurodegenerative disorders. We describe the clinical presentation of HAND, review existing data related to screening tools, and provide preliminary and practical recommendations in the absence of more definitive studies.
 
THE SCOPE OF COGNITIVE DISORDERS IN THE ERA OF COMBINATION ANTIRETROVIRAL THERAPY
 
Human immunodeficiency virus (HIV) is neurovirulent. Prior to widespread availability of combination antiretroviral therapy (cART), the prevalence of HIV-associated dementia was estimated to be between 6 and 30% among patients with AIDS. With treatment, the frequency of dementia is attenuated, but milder forms of impairment remain highly prevalent and increase with age [1]. Less severe impairment correlates to measurable abnormalities on tasks associated with daily functioning, thus deeming them important clinical syndromes [2]. The presence of symptomatic cognitive impairment predicts non-central nervous system (non-CNS) morbidity and overall HIV mortality [3].
 
The current diagnostic categories of HAND are designed for research settings and emphasize performance on comprehensive neuropsychological testing batteries [4]. The most severe form of impairment is HIV-associated dementia (HAD), requiring test performance >2 standard deviations below average in 2 cognitive domains (eg, memory and executive function) and marked evidence of impaired daily function. Mild neurocognitive disorder (MND) similarly requires confirmation of impact on daily activities, but to a lesser degree, and involves less-severe neuropsychological impairment. A third diagnostic category, asymptomatic neurocognitive impairment (ANI), is used for participants with impaired neuropsychological performance in the absence of identifiable functional deficits. Such cases are frequent in research settings. A recent survey of 1555 community-dwelling HIV-positive participants in the United States reported HAD frequency at about 2%, but identified non-HAD impairment in 45% of participants who lacked major confounding factors (12% MND and 33% ANI) [1]. Thus, among impaired participants, most were asymptomatic. Using impairment ratings rather than diagnostic categories, 1 group [5] noted no change in the frequency of impairment when comparing pre- and post-cART eras. In short, the frequency of severe impairment has decreased with cART, but the frequency of all severities of cognitive impairment appears to be unchanged. Cognitive impairment is often present among individuals who do not endorse functional symptoms when asked. Asymptomatic neuropsychological testing abnormalities may not represent disease in all participants, and there is a substantial lack of clarity regarding the long-term clinical implications of ANI. The frequency of neuropsychological abnormalities among ANI participants exceeds the variability inherent in neuropsychological testing, and studies demonstrating everyday functional abnormalities that correlate to testing impairment do not require symptoms [2]. These testing abnormalities may sometimes be severe and occasionally correlate to MRI changes (Figure 1). Together, this information suggests that ANI does not represent disease-free baseline performance for many individuals. The designation of "asymptomatic" may more accurately reflect our inability to document impaired function, possibly related to lack of insight, frontal lobe processing deficits, limited daily activity (floor effect), or poor objective proxy information. Undetected cognitive impairment may increase the risk of poor adherence, lead to financial errors, or result in other adverse outcomes [2, 6]. Because functional impairment is the cornerstone of diagnosing dementia, optimal assessments may require objective evaluation of everyday function.
 
AGING AND COGNITIVE DISORDERS IN HIV
 
Nearly all studies investigating the effects of age on the frequency of HAND identify increased risk, although data are mixed when considering only neuropsychological testing performance [7]. Few studies include sufficient numbers of cases over age 60 and none have systematically addressed potential non-HIV etiologies such as Alzheimer's disease (AD). In older participants, comorbidities such as cumulative cerebrovascular disease may have significant contributions.
 
The risk for acceleration of neurodegeneration in HIV has been raised, though the issue currently remains largely theoretical. Proteins associated with age-related neurodegenerative disorders, such as ubiquitin, amyloid, and tau, have been noted in neuropathological tissues with some studies noting a higher frequency of these proteins in the era of cART [8]. Prior to cART, pathologists noted accumulation of amyloid protein in diffuse but nonneuritic plaques, with neuritic plaques being the hallmark of AD [9]. A report using an amyloid-specific positron emission tomography (PET) ligand, Pittsburgh compound B (PIB), in younger, healthy and nonimpaired HIV-positive participants failed to identify a pattern of uptake that would be typical for AD [10]. The PIB compound identifies only neuritic and not diffuse plaques, and this work must be extended to a population of older participants where sufficient baseline risk for AD exists. Ultimately, longitudinal evaluations may be essential, because HAND is more likely to present as static impairment with some fluctuation rather than the relentless insidious deterioration that is the cornerstone of neurodegenerative disorders [4].
 
CLINICAL CHARACTERISTICS OF HIV-ASSOCIATED DEMENTIA-IMPACT ON SCREENING TOOLS
 
HIV enters the central nervous system (CNS) during acute infection; however, neurons remain largely uninfected and the primary mechanism of brain injury relates to extensive inflammation leading to neuronal dysfunction and synaptodendritic injury [8]. Early studies identified HIV staining concentrated in subcortical and deep grey matter structures, an anatomy that informs the clinical presentation of HAND, with motor, behavioral, and predominantly subcortical cognitive features [11]. Early neuropsychological screening batteries were designed with a focus on these subcortical features, targeting psychomotor speed and information processing as well as executive functioning and memory. The clinical-anatomic correlations are further bolstered by findings associating cognitive impairment and apathy to deep grey matter structures, principally the caudate nucleus and the nucleus accumbens, respectively. Extrapyramidal motor features are often observed and increase with age [12]. Although memory deficits occur, the pattern typically involves inefficient learning and problems with executive functioning and retrieval rather than pure difficulty in formulating a memory itself (encoding deficits) [13]. These features contrast sharply with the cortical deficits typical of AD where encoding of new memories is common. Screening instruments intended for older HIV-positive populations will need to consider both presentations. The motor deficits observed in HIV are generally not seen in early stage AD but may be seen in Parkinson disease-spectrum disorders. The added increased frequency of cerebrovascular comorbidity in HIV may further complicate the clinical scenario.
 
SCREENING RECOMMENDATIONS FOR DEMENTIA IN HIV-NEGATIVE POPULATIONS
 
Most agencies provide mixed or limited support for routine screening for dementia in HIV-negative populations, despite knowledge that dementia remains frequently underdiagnosed [14]. Citing limited outcome data for clinical intervention, effects related to stigma associated with cognitive disease, and lack of specificity for existing screening instruments, the most recent (2003) United States Preventative Service Task Force (USPSTF) guidelines concluded that there is insufficient evidence to recommend for or against routine screening in the absence of known impairments [15]. The recommendations suggest screening for patients who exhibit functional changes. The American Academy of Neurology recommends increased screening for patients with mild cognitive impairment (MCI) due to heightened risk for progression to dementia; however, for asymptomatic elders, it concurs with the USPSTF [16]. Past recommendations from the American Geriatric Society, the American Medical Association, and the American Academy of Family Physicians similarly focus on symptomatic disease rather than screening asymptomatic participants [17].
 
HIV DEMENTIA SCREENING TOOLS
 
The most commonly referenced HIV screening tool is the HIV Dementia Scale (HDS) [18]. This tool provides a rapid assessment of eye movements, motor skills, simple learning, and attention. The HDS performance characteristics are modest with acceptable sensitivity only for the most severe disease. For example, among hospitalized patients, 12% of whom met clinical criteria for HAD, the sensitivity at a cut-point of 10 (out of 16) was 0.92 and the specificity was 0.71, resulting in a positive predictive value (PPV) of 0.3 and a negative predictive value (NPV) of 0.98 [19]. The performance characteristics are much worse for detecting milder impairment [20, 21]. A study of HIV-positive individuals interested in returning to work noted sensitivity and specificity for all impairment to be only 39% and 85%, respectively [22].
 
Adjusting for age and education substantially improves performance but simultaneously complicates interpretation for primary care settings. Even with adjustment, the HDS demonstrates only modest ability to identify impairment (70% sensitivity) [23]. A modified version (mHDS) excludes the antisaccade eye movement task, which may be the most sensitive aspect of the HDS. The mHDS was no better than a simple test of psychomotor speed and manual dexterity (the grooved pegboard test) in identifying dementia [24]. Substantial educational attainment effects have also been noted [25]. Taken together, these data are concerning that the HDS is suboptimal for most HAND patients given that HAD constitutes <5% of impaired cases among community-dwelling adults.
 
Reliance on patient self-report of symptoms is not ideal. Studies have revealed limited correlation between self-reported memory impairments and performance on objective neuropsychological tests, and tighter association with depressive symptoms. The Patient Assessment of Own Functioning (PAOF), for example, identified depressive symptoms and psychomotor inefficiency rather than neuropsychological testing performance, and when applied to HIV-negative substance abusers, there was no correlation to neuropsychological testing performance [26, 27]. Importantly, screening for symptoms would not identify ANI, the largest subset of impaired participants. It is possible that, combined with a clinical risk identification schema that includes risk factors such as CD4 nadir count, plasma viral load, and age, these metrics could be improved, given reports that such clinical variables may have some utility [28].
 
Computer-delivered cognitive assessments have a theoretical benefit in that they alleviate the time burden on clinical staff. In the pre-cART era, the Sequential and Choice Reaction Time Program (CALCAP), a measure of reaction time, attention, psychomotor speed, and memory, identified advanced disease but not milder disease [29, 30]. More recently, the CogState was evaluated and similarly performed well in identifying advanced dementia [31]. A pilot study revealed some promise in using the Computer-based Assessment of Mild Cognitive Impairment (CAMCI); however, the study design and size limited interpretation for the clinical setting [32]. In general, computer approaches have several important limitations including an inability to test verbal learning efficiency, complicated outputs requiring interpretation, cost burdens, limitations in the face of literacy and non-English speakers, and a need to train staff.
 
Understanding which subtests within comprehensive batteries best correlate to cognitive impairment could provide pivotal information for screening tool development. A domestic study noted that a combination of tests tapping verbal memory (Hopkins Verbal Learning Test-revised total recall) and psychomotor speed (Grooved Pegboard or digit symbol modalities) emerged as best predictors of rater-determined impairment [33]. The combined tests outperformed the HDS. A second international trial noted that verbal learning efficiency (WHO-UCLA auditory verbal learning sum of trials 1-5), psychomotor speed (digit symbol modalities test) and motor speed (timed gait) together best distinguished HAD from non-HAD cases among cART-naive advanced HIV-positive participants [34].
 
However, the time needed to perform the list-learning task (verbal learning efficiency) in each study effectively precludes its use in simple screening instruments. A shorter battery that was limited to tests of psychomotor speed (digit symbol, Trails A) and cognitive flexibility (Trails B) generally performed worse in accurately categorizing impairment (60% of cases when less stringent cut-points were used) [35].
 
There are considerable differences between screening tools for HIV and those with utility for other disorders encountered in older age. The most widely used screening tool for AD, the Mini Mental State Exam (MMSE), does not test executive function or motor skill, rendering it less sensitive to subcortical neuropathology, and limited investigations confirm poor sensitivity to HAND [36, 37]. Among the first 75 cases enrolled into the UCSF Memory and Aging HIV Cohort (all with age >60 years), the MMSE did not appear to provide sufficient variability by cognitive group to help diagnostically [mean score out of 30 possible points (sample size, standard deviation) were as follows: normal cognition: 29.3 (37, 0.75); ANI: 28.7 (13, 1.49); MND: 28.3 (20, 1.26) and HAD: 23 (4, 11.37) (unpublished data). Notably, the HAD group included 1 patient thought to have comorbid advanced AD and an MMSE score of 6]. Overall, the narrow distribution of these scores demonstrates poor likelihood of utility even in aged HIV-positive participants.
 
In summary, studies related to screening have broad limitations, are often underpowered, and attempt to identify only the most severe form of impairment (Table 1). Nearly all have been completed in younger populations; it is anticipated that the performance characteristics would be even less favorable in older participants. There are insufficient data to make firm recommendation on optimal screening tools, but it appears clear that the MMSE is not a good choice.
 
SHOULD WE SCREEN FOR COGNITIVE IMPAIRMENT AND IF SO, HOW?
 
We could find no published dementia screening guidelines in the setting of HIV. The American Academy of HIV Medicine recently convened a panel to address clinical recommendations for aged HIV-positive participants. These recommendations, still unpublished, will likely focus on symptomatic cases (personal communication as a panel member). It is critical that practical recommendations consider competing priorities in complex HIV care settings. The use of comprehensive neuropsychological batteries is not feasible for screening. The USPSTF compiled a series of key questions to consider in developing cognitive screening recommendations, considered in the context of a predominantly HIV-negative population (Table 2). Although these may serve as a template for future studies, because most of these questions are inadequately addressed in HIV, recommendations must necessarily be based on empiric evidence and expert opinion.
 
Prevalence estimates of cognitive impairment differ substantially among studies owing to differing methodological approaches and study populations. More impairment is typically noted in studies with more untreated participants, persons with AIDS, or older participants. Choice of normative data may also influence prevalence estimates. When compared with coenrolled risk and demographically matched HIV-negative groups, the differences in neuropsychological testing performance associated with HIV appear less than would be anticipated in comparison with studies that utilize published normative data. This suggests that some of the impairment noted in HIV-positive populations is influenced by other coexisting factors that are absent in published control data sets. In the current era, the prevalence of cognitive impairment in HIV infection appears to be high, estimated at 46% in cases without severe confounding factors when published controls are used for comparison [1]. Among these impaired participants, most are asymptomatic (meet ANI criteria). Neuropsychological impairment has been linked to medication adherence; however, there are no studies demonstrating that early identification will impact adherence. Based on our knowledge from HIV-negative populations, other potential benefits of early recognition may ensue, including protection from unsafe situations and financial abuse, and increased quality of life through information sharing and improved life planning [38]. Generally, providing information to patients is an important aspect of clinical care and serves as a mechanism to develop or implement compensatory strategies to maintain independence.
 
Medication treatment strategies for impairment have been disappointing. The potential benefits of CNS-penetrant antiretroviral drugs in the setting of long-term plasma suppression of virus are unclear despite published case series where intervention to change antiretroviral choice is required [39]. Should clear data emerge recommending specific treatment strategies, or should adjuvant treatments prove to be efficacious, the need for early identification would be greater. Identification of cognitive impairment could provide a stimulus for starting cART in ART-naive patients, or signal the need for intensified adherence counseling in those patients already receiving treatment. Among impaired participants with comorbid conditions that may lead to cognitive impairment (eg, obstructive sleep apnea, coexisting neurovirulent infections such as syphilis, vitamin deficiencies, and metabolic derangements), it is reasonable to believe that treatment may improve cognition. Counseling to avoid psychoactive medications and illicit drugs may also be advantageous. In summary, it is likely that identifying impairment may impact treatments aimed at improving quality of life, but intervention trials are lacking and this effort must be considered within the context of competing priorities for primary care settings. Given the frequency of cognitive impairment in the HIV-positive population, screening is likely to identify far more truly impaired cases than false-positive cases.
 
GENERAL RECOMMENDATIONS AND CONCLUSIONS
 
At this point, only general recommendations can be made regarding appropriate screening tools for HAND. Both HIV and cerebrovascular disease-specific pathology would be expected to demonstrate preferential subcortical involvement, thereby negating the utility of screening measures that do not adequately tap cognitive domains and effectively excluding use of the MMSE as a screening tool. Currently available HIV-targeted screening instruments, such as the HDS, have marked limitations in that they are sensitive only for the most severe forms of impairment.
 
Screening tools that tap both cortical and subcortical processes exist, but have not been broadly used in HIV. Among such tools is the Montreal Cognitive Assessment (MoCA), which is free (http://www.mocatest.org/) and translated (but not necessarily validated) in many languages. The MoCA provides some coverage of executive function, motor skill, language fluency, and verbal learning. To date, the MoCA has been tested in a pilot study of 119 relatively young (mean age 43 years) participants identifying 45 of 78 impaired participants (59%) at a cut-point of ≤25 (PPV: 85%, NPV: 53%). Shifting the cut point to 27 increased sensitivity but overall performance characteristics were not reported [40]. A recent publication identified that the MoCA may benefit from modifications designed to increase difficulty of some items for application in typical HIV clinics [41]. Other tests that combine list-learning tasks with tasks of cognitive flexibility and psychomotor speed may be superior. Individuals with symptoms may require more in-depth neuropsychological testing if screening is negative, because false-negative cases occur with all screening tests. This should be combined with a screen for depression (eg, Back Depression Scale-II). These can be completed in about 10 minutes. Use of only symptom-based screening tools is likely to miss >50% of impaired cases. The addition of a neurological examination focused on motor speed, tone, and reflexes and integration with clinical variables (eg, CD4 nadir, viral load) may add specificity.
 
Overall, there are important considerations for early detection of cognitive impairment, particularly among older HIV-positive patients. Unlike the general healthy population, older HIV-positive patients are managing a complex medical condition that disrupts CNS integrity and cognitive function and may be life threatening if not adequately controlled through medical intervention. With HIV, treatment failure and broad antiretroviral medication resistance are potential outcomes of cognitive impairment. As such, unlike in the healthy older population, failure to identify cognitive deficits in the HIV-positive population may directly influence successful management of the disease. In balance, there are important clinical needs that can be addressed by research aimed at demonstrating whether improved detection results in improved outcomes.
 
 
 
 
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