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Diabetes in HIV & Globally - "turn attention to the diabetes epidemic, which he estimated will affect nearly 600 million people within 20 years."
  CROI 2011: "Diabetes Mellitus in Treated HIV-Infected Patients: Incidence over Ten Years in 1,046 patients from the ANRS CO8 APROCO-COPILOTE Cohort"

"In the multivariate analysis, a higher incidence of diabetes was associated with: age >40y (Hazard Ratio [HR]: 2.13, p<10-4 ), BMI >25 kg/m2 (HR: 1.98, p=0.003), waist-to-hip ratio ≥0.97 male/0.92 female (HR: 3.95, p<10-4 ), lipoatrophy (HR: 1.92, p=0.007) and exposure to indinavir (HR: 1.92, p=0.001), stavudine (HR: 2.77, p<10-4 ) or didanosine (HR: 1.51, p<0.05). Patients who developed diabetes presented at baseline a 10% 10-year risk of cardio-vascular disease (Framingham score) vs 3% in normoglycemic patients."

Diabetes Mellitus in Treated HIV-Infected Patients: Incidence over ... -

Mar 2, 2011 - Diabetes Mellitus in Treated HIV-Infected Patients: Incidence over Ten Years in 1046 patients from the ANRS CO8 APROCO-COPILOTE Cohort


"Every 7 seconds, somebody, somewhere in the world, dies because of diabetes," Jean Claude Mbanya, MD, PhD, president of the International Diabetes Federation (IDF), said at a press conference.

The disease can be managed with diet, exercise and medication but chronically high blood sugar levels causes nerve damage, which can result in kidney disease, blindness and amputation.

In June, a study published in the medical journal Lancet estimated the global number of diabetes had more than doubled in the last three decades and put the figure at 347 million.

Experts said much of the rise in diabetes cases was due to aging populations - since diabetes typically hits in middle age - and population growth, but that obesity rates had also fueled the disease's spread.

Type 1 diabetes mainly affects children and young adults, who are unable to make insulin. Type 2 diabetes is more common and is often tied to obesity. It develops when the body doesn't produce enough insulin to break down glucose, inflating blood sugar levels.

A call to action

Andrew Boulton, MD, vice president of the European Association for the Study of Diabetes (EASD), acknowledged the "staggering" socioeconomic impact of diabetes and all non-communicable diseases.

"EASD fully supports the IDF and echoes the call of Professor Mbanya's for increased funds for medical research," Boulton stated in a press release.

Such research includes developing approaches for building local health care capacity and integrating diabetes care and services with primary health care, management of chronic infectious diseases and maternal and child health.

"Investing in research now will result in greater cost savings in the future," Mbanya said at the meeting. "Confronted with [the latest Diabetes Atlas] statistics, we have been more than resolve at the IDF to challenge the government to find solutions in order to tackle this problem."


Diabetes Estimate Now 366 Million

By Kristina Fiore, Staff Writer, MedPage Today

LISBON -- About 366 million people worldwide have diabetes, according to the latest figures from the International Diabetes Federation (IDF), released in advance of a United Nations summit on non-communicable diseases in New York next week.

That's up from 300 million estimated in the 2009 edition of the organization's Diabetes Atlas. This year's edition will be published in mid-November.

The new edition also estimates 4.6 million deaths from the disease annually, Jean Claude Mbanya, MD, president of the IDF, said during a press briefing at the European Association for the Study of Diabetes (EASD) meeting here.

"We don't want world leaders to forget diabetes, which is a tsunami of the 21st century," Mbanya said regarding the early release of the figures.

He added that the numbers are likely underestimated, since not all countries have good data on prevalence estimates. For countries with insufficient data, the researchers have to make conservative estimates based on data from neighboring countries, he said.

Mbanya urged world leaders at next week's summit, the first on this type of disease and the second on a global disease issue, to turn their attention to the diabetes epidemic, which he estimated will affect nearly 600 million people within 20 years.

He noted that overall global spending on patient care for diabetes is $465 billion.

EASD president Ulf Smith, MD, said the summit is important, given the fact that non-communicable diseases -- including diabetes, respiratory disease, cardiovascular disease, and cancer -- are the major causes of death in the world.

"We are hoping that the world will identify non-communicable diseases as a major challenge to health," Smith said.

The summit was on the radar screen of attendees at this year's EASD meeting, which drew more than 18,000 participants, along with 2,145 abstracts that were whittled down to 1,294.

Top abstract contributors were the U.S. with 146, the U.K. with 139, Germany with 114, Italy with 94, and Japan with 87, according to Mark Walker, MD, chair of the meeting's scientific program committee.

Walker noted that China and Korea also made a good showing in abstracts this year, with China moving to the middle of the pack with 37 abstracts, and Korea contributing 20.

However, Walker said there are no late-breaking sessions because no data this year warranted that type of attention.

"The reality is that we've been scanning the horizon, but we believe there were none of high importance," he said during the briefing. "We didn't think there were trials of sufficient high quality."

Smith also noted that Europe has been lagging behind in diabetes research and funding for research - potentially a symptom of economic woes in European countries.

At the present funding rate, Smith said, China's research funding will surpass that of the European Union by 2014.

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