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Intermittent Prophylaxis with Oral (Gel)
Truvada Protects Macaques from Rectal SHIV Infection
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Intermittent Prophylaxis with Oral Truvada Protects Macaques from ...
www.natap.org/2010/HIV/031910_02.htm
Intermittent Prophylaxis with Oral Truvada Protects Macaques from Rectal SHIV Infection. Sci Transl Med 13 January 2010
"We tested this hypothesis by intermittently giving prophylactic Truvada to macaque monkeys and then exposing them rectally to simian-human immunodeficiency virus (SHIV) once a week for 14 weeks. A simple regimen with an oral dose of Truvada given 1, 3, or 7 days before exposure followed by a second dose 2 hours after exposure was as protective as daily drug administration, possibly because of the long intracellular persistence of the drugs. In addition, a two-dose regimen initiated 2 hours before or after virus exposure was effective, and full protection was obtained by doubling the Truvada concentration in both doses. We saw no protection if the first dose was delayed until 24 hours after exposure, underscoring the importance of blocking initial replication in the mucosa. Our results show that intermittent prophylactic treatment with an antiviral drug can be highly effective in preventing SHIV infection, with a wide window of protection. They strengthen the possibility of developing feasible, cost-effective strategies to prevent HIV transmission in humans."
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Prevention of Rectal Simian HIV Transmission in Macaques by Intermittent Pre-exposure Prophylaxis with Oral Truvada
Reported by Jules Levin CROI Feb 2009
Prevention of Rectal Simian HIV Transmission in Macaques by ...
www.natap.org/2009/CROI/croi_189.htm
Conference on Retroviruses and Opportunistic Infections Montreal, Canada ... in Macaques by Intermittent Pre-exposure Prophylaxis with Oral Truvada ... rectal transmission model consisting of 14 weekly virus (simian HIV [SHIV]162p3,10 ... I and 5 of 6 from group II were protected; the risk of infection was reduced by 3.9
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Efficacy of Intermittent Prophylaxis with Tenofovir and Emtricitabine against Rectal SHIV Transmission in Macaques and Relationship to Systemic and Mucosal Drug Levels
Reported by Jules Levin
CROI 2010
Efficacy of Intermittent Prophylaxis with Tenofovir and Emtricitabine ...
www.natap.org/2010/CROI/croi_170.htm
and Opportunistic Infections ... Background: Intermittent pre-exposure prophylaxis (iPrEP) with long-acting drugs is a ... Methods: Efficacy was evaluated by a repeat-challenge macaque model consisting of up to 14 weekly rectal SHIV exposures. Truvada was given orally to groups of 6 macaques according to the following .
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Truvada Protects Macaques From Rectal Exposure to FTC-Resistant Virus
International HIV and Hepatitis Drug Resistance Workshop, June 8-12, 2010, Dubrovnik, Croatia
Truvada Protects Macaques From Rectal Exposure to FTC-Resistant ...
www.natap.org/2010/ResisWksp/ResisWksp_11.htm
Intermittent oral prophylaxis with tenofovir/emtricitabine (Truvada) protected all 5 ... prophylaxis with oral truvada protects macaques from rectal SHIV infection
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Intermittent Truvada PrEP Offers Monkeys Some Protection
3rd International Workshop on HIV Transmission:
Principles of Intervention
July 31-August 2, 2008, Mexico City
Intermittent Truvada PrEP Offers Monkeys Some Protection
www.natap.org/2008/Trans/Trans_06.htm
Aug 2, 2008 - But two-dose PReP did not protect all animals in any of the four ... Trials of daily Truvada PrEP are now under way in different human populations at high risk of HIV infection. ... Intermittent pre-exposure prophylaxis (PrEP) with oral Truvada protects macaques against repeated rectal SHIV exposures
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Tenofovir/Emtricitabine Gel Protects Female Monkeys From SHIV
3rd International Workshop on HIV Transmission:
Principles of Intervention
July 31-August 2, 2008, Mexico City
Tenofovir/Emtricitabine Gel Protects Female Monkeys From SHIV
www.natap.org/2008/Trans/Trans_05.htm
Aug 2, 2008 - Intermittent pre-exposure prophylaxis (PREP) with oral Truvada protects macaques against repeated rectal SHIV exposures. 3rd International
· Protects Macaques Against Repeated Rectal SHIV ... - NATAP
www.natap.org/2007/ResisWksp/ResisWksp_49.htm
Intermittent Antiretroviral Prophylaxis with Tenofovir and Emtricitabine (FTC) Protects Macaques Against Repeated Rectal SHIV ... Findings illustrate the high vulnerability of SHIV to potent interventions during the initial stages of mucosal infection. ... Comparison group (n=6): daily PrEP with oral TDF (22 mg/kg) and oral FTC ...
· Two Doses of Tenofovir/FTC Protect Monkeys From Rectal Simian HIV
www.natap.org/2007/HIV/082807_05.htm
If the same holds true in humans, intermittent timed dosing could prove just as ... as daily pre-exposure prophylaxis (PrEP), a strategy being tested in three trials. ... SHIV infected 2 of the 6 macaques who got a single TFV/FTC shot 2 hours ... of Truvada (coformulated TDF/FTC) 2 hours before and 24 hours after 14 rectal
· Prevention of Rectal SHIV Transmission in Macaques by Daily or ...
www.natap.org/2008/CROI/croi_109.htm
Feb 5, 2008 - Pre-exposure prophylaxis (PrEP) with antiretroviral drugs could prove to be an ... The risk of infection in macaques treated in groups 1 and 2 was 3.8- and ... All six animals in group 4 that received intermittent PrEP were protected. ... Earlier studies in newborn macaques exposed orally to a highly virulent ...
· Higher ART TDF/FTC Potency Correlates with Increased Protection ...
www.natap.org/2007/CROI/croi_76.htm
Chemoprophylaxis with antiretroviral drugs as a strategy to prevent the ... with two different doses of tenofovir to protect macaques against rectal SHIV ... FTC/TDF (20 mg/kg FTC and 22 mg/kg TDF) at a dose equivalent to Truvada in humans. ... (In group 2 macaques (oral FTC/TDF), only 2 of the 6 animals become infected ..
· HIV Treatment HIV Medications Selected Articles
www.natap.org/hiv.htm
Intermittent Prophylaxis with Oral Truvada Protects Macaques from Rectal SHIV Infection - (03/19//10); CROI: Efficacy of Intermittent Prophylaxis with Tenofovir ...
· Prevention of Rectal SHIV Transmission in Macaques by Tenofovir ...
www.natap.org/2006/CROI/CROI_23.htm
These study results were presented at the 13th CROi in an oral session by Walid ... protected all 6 treated animals from infection after 14 repeated rectal SHIV exposures. ... Data suggest that chemoprophylaxis with a potent antiretroviral drug ... The observed protection by tenofovir and FTC may not reflect that of Truvada, ...
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