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Reversibility of tenofovir-associated decline in renal function
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Reported by Jules Levin
CROI 2013
Sophie Jose1, Lisa Hamzah2, Lucy Campbell2, Dorothea Nitsch3, Rachael Jones4, Caroline Sabin1 and Frank Post2 for the UK Collaborative HIV Cohort (CHIC) Study
1UCL Medical School, Royal Free Campus, London, UK; 2Kings College London, London, UK, 3London School of Hygiene and Tropical Medicine, London, UK, 4Chelsea and Westminster NHS Trust, London UK
from Jules: in speaking with author they did not have in the database information regarding whether patients had diabetes
That's the reason for our cautious interpretation stating that incomplete reversibility may reflect "progression of the underlying CKD (such as diabetic nephropathy), the effects of co-morbidities or concomitant medications, or an irreversible effect of TDF on kidney function".
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