Cardiac function is altered in Aged Transgenic AIDS Mice in vivo: Insights into Age-related HIV-1 Changes in Patients
Reported by Jules Levin
Rebecca A. Torres, Earl J. Fields, Tomika Ludaway, Rodney Russ and William Lewis
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322
Left ventricular mass and end diastolic diameter are increased in aged HIV-1 transgenic mice
Figure 1. A comparison of cardiac function in both young and aged HIV-1 transgenic mice . Two-dimensional M-mode echocardiographic analyses were performed on both young (~3 months) and old (~18 months) wild-type and HIV-1 (MSB) mice. Data analyses revealed a significant increase in LV mass and LVEDD in aged HIV-1 transgenic mice as compared to aged-matched wild-type control animals. There was no difference observed in LVFS between either groups. All summary data are presented as mean ±SEM (*p<0.05) (n=≥6/group).