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Hepatitis C Co-infection and the Risk of Chronic Kidney Disease in HIV-infected Individuals:
Does Hepatitis C Viremia Matter?
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Reported by Jules Levin
CROI 2013
Gregory Lucas, Yuezhou Jing, Mark Sulkowski, Alison Abraham, Mohamed Atta, Derek Fine, Richard Moore, Michelle Estrella for the NA ACCORD of IeDEA
Johns Hopkins University, Baltimore, MD, USA
"We found that both HCV viremic and HCV aviremic HIV-infected persons were at increased risk of moderate and advanced CKD compared to HCV seronegative persons, suggesting that factors other than chronic HCV replication mediate increased CKD risk in HCV-infected individuals."
HCV viremic subjects were at adjusted 36% increased risk for stage 3 CKD, stage 5 CKD 94% and progressive CKD 30% (1.30 [1.18, 1.43], while HCV aviremic subjects were also increased risk for stage 3 CKD 19%, stage 5 CKD 68% and progressive CKD 31% . Aviremic patients were also at risk but less risk, see poster report below.
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