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A Longitudinal Study of the Effects of Ageing and HIV-1 Infection on Cognitive Performance
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Reported by Jules Levin
CROI 2013
B Haynes1, K Towgood1, S Casey2, J Dunn1, F Zelaya1, M Pitkanen1, R Kulasegaram3, G Barker1 & M Kopelman1 1King's College London, Institute of Psychiatry, London UK 2Aquired Brain Injury Ireland, Dublin Ireland 3Guys and St Thomas' NHS Foundation Trust, London UK
Abstract
Methods At baseline 20 younger (age 20-40) and 20 older (age 50-75) HIV-1 infected men were assessed on a broad cognitive test battery and compared to 20 younger and 22 older age and education matched controls. All patients were stable on HAART, with undetectable viral loads. The follow-up assessment, approximately four years after baseline, used the same test battery. Change scores were analysed using 2x2 analysis of variance, looking for a three way interaction between HIV status, age group and time. Results We report results from follow-up data on 53 individuals. There were significant (p<.05) interactions on global cognition and the visuo-spatial domain, and a trend (p<.10) on executive function. Follow-up investigation showed greater decline in the older HIV+ group than the HIV- older group, with no difference between the younger groups. Conclusions Despite no baseline differences, the present results hint towards greater cognitive decline in the older HIV+ group, which would support the notion of an interaction between HIV infection and ageing. This was most pronounced when the domains were combined into a global cognition measure. Results from the full sample at follow up will allow more definitive interpretations and correlations with imaging findings will be examined.
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