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Neuroimaging Correlates of Prior Immunosuppression and Cognitive Status in HIV
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......study found 'Worse neuronal integrity correlated with greater past immune suppression' [nadir cd4]......'HAND was most strongly associated with lower neuronal integrity and more extensive abnormal white matter, which may reflect persistent HIV-related inflammation'.......'Earlier initiation of ART to prevent advanced immune suppression may reduce brain injury and cognitive impairment, although the impact of ongoing neuroinflammation needs further investigation'
Reported by Jules Levin
CROI 2013
C Fennema-Notestine1*, MJ Taylor1, RJ Notestine1, T Wolfson2, AC Gamst1, SL Archibald1, RJ Theilmann1, RK Heaton1,
C Marra3, and I Grant1 for the CHARTER Group 1University of California, San Diego, La Jolla, CA; USA; 2Computational and Applied
Statistics Laboratory at the San Diego Supercomputer Center (SDSC), La Jolla, CA, USA; 3University of Washington, Seattle, WA, USA
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