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Longitudinal Association of HIV-associated neurocognitive disorder (HAND) with Frailty in HIV+ Men
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Reported by Jules Levin
CROI 2013 Atlanta March 3-6
Bryan Smitha, Richard Skolaskyb, Ola Selnesa, James Beckerc, Lisa Jacobsond, Joseph Margolickd, Eileen Martine, Eric Millerf, Ned Sacktor, MDa, for the Multicenter AIDS Cohort Group
aJohns Hopkins University Department of Neurology; bJohns Hopkins University Department of Orthopaedic Surgery; cUniversity of Pittsburgh Department of Psychiatry; dJohns Hopkins University School of Public Health; eUniversity of Illinois-Chicago Departments of Psychiatry and Neurology; fUniversity of California-Los Angeles Department of Psychiatry
CONCLUSIONS
· Those affected by HIV-associated neurocognitive disorder have a higher odds of incident frailty.
· Symptomatic HAND, and all forms of HAND, predict a greater odds of developing 4 of the 5 frailty phenotype criteria (grip strength, walking speed, physical exhaustion, and physical activity).
· Impairments in speed, motor function, executive function, or learning increase the odds of incident frailty for those with HIV.
"Table 2. HIV+ participants with symptomatic HAND also had a shorter duration of HIV infection and were more likely to be black, non-Hispanic than those with normal cognition. Additionally, those with symptomatic HAND were more likely to have a college education than those with normal cognition."
Graph 3, those with HAND develop frailty more quickly
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