icon-    folder.gif   Conference Reports for NATAP  
  21st Conference on Retroviruses and
Opportunistic Infections
Boston, MA March 3 - 6, 2014
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Impact of Smoking on Risk of Cancer among HIV patients Compared to the Background Population
  Reported by Jules Levin
CROI 2014 March 3-6 Boston, MA
Helleberg M, Gerstoft J, Afzal S, Kronborg G, Larsen CS, Bojesen SE, Court Pedersen C, Nordestgaard BG, Obel N
Dept. of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen; The Copenhagen General Population Study and Dept. of Clinical Biochemistry, Copenhagen University Hospital, Herlev Hospital, Herlev; Dept. of Infectious Diseases, Copenhagen University Hospital, Hvidovre; Dept. of Infectious Diseases, Aarhus University Hospital; Dept. of Infectious Diseases, Odense University Hospital, Odense; Denmark


from Jules: Note in this table the cancer incidences in HIV+ vs HIV-negatives control group, particularly in general those cancers that are smoking-related & virological show much higher rates of cancer in HIV+ while in most but not all cancers the rates among HIV+ are similar among the ŇotherÓ group to HIV-negative control group.




CI: confidence interval, aIRR: adjusted incidence rate ratio, PAF: population attributable fraction. 1IRR estimated using Poisson regression analyses adjusted for gender, age and year of study inclusion. 2+3Calculated using the formula: PAF = Pe*(RRe-1)/(1+Pe*(RRe-1)), where Pe is the proportion of time with exposure and RRe is the adjusted relative risk of cancer among exposed compared to unexposed. 2Exposed: HIV-infected individuals, unexposed: population controls. The RRe is calculated as the weighted average of ever-smoking HIV-infected individuals versus ever-smoking controls and never-smoking HIV-infected individuals versus never-smoking controls. 3Exposed: ever-smoking HIV-infected individuals, unexposed: never-smoking HIV-infected individuals.