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Persistence of HIV Associated Neurocognitive Disorders (HAND) in the Combination Antiretroviral Therapy Era (cART)
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Reported by Jules Levin
16th International Workshop on Co-morbidities and Adverse Drug Reactions in HIV 6 October 2014, Philadelphia USA
Beau M. Ances, MD, PhD, MSc, FANA
Associate Professor
Departments of Neurology, Radiology,
Biomedical Engineering, Microbiology
Washington University in St. Louis
Independent Effects of HIV, Aging, and HAART on Brain Volumetric Measures: 'HIV Atrophies Brain Despite HAART/HIV Aged Brain 17 Yrs Faster/Evaluation Tests'......http://www.natap.org/2012/HIV/020912_02.htm (JAIDS, Ances)......"this study has demonstrated that HIV continues to be associated with brain atrophy within subcortical regions in the HAART era.....In our cohort, HIV led to approximately 17 years of aging of the brain. For every 10 years, HIV led to a 6% decrease in caudate volume, whereas aging resulted in a 4% decrease......our results suggest that a decrease in brain integrity within older HIV+ participants, even those taking HAART, may indicate that these individuals have increased vulnerability for subsequently developing neurodegenerative disorders.....On average, most HIV+ participants were taking regimens with relatively good brain penetration (average CPE = 7).....Despite the introduction of HAART, changes in brain structure have persisted within impaired and cognitively normal HIV+ individuals.......more than 50% of all HIV+ participants in the United States will be more than 50 years old by 2015.3 Older HIV+ participants may be at increased risk for accelerated body aging.......Given the continued prevalence of HAND despite HAART, isolating additional factors that might influence brain integrity will be crucial for determining if and when neuroprotective interventions should be administered. The aim of this study was to determine the effects of HIV, HAART, and aging on subcortical and cortical brain volumetric measures"
Independent Effects of HIV, Aging, and HAART on Brain Volumetric Measures: 'HIV Atrophies Brain Despite HAART/HIV Aged Brain 17 Yrs Faster/Evaluation Tests'......http://www.natap.org/2012/HIV/020912_02.htm (JAIDS, Ances)
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