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Persistently Increased Ischemic Stroke Risk in HIV-Infected Women
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Reported by jules Levin CROI 2016 Feb 22-24 Boston
Felicia C. Chow,1 Susan Regan,2 Sara E. Looby,2 Markella V. Zanni,2 James B. Meigs,2 Cheryl D. Bushnell,3 Steven K. Feske,4 Steven K. Grinspoon,2 Virginia A. Triant2
1University of California San Francisco, San Francisco, CA, U.S.A., 2Massachusetts General Hospital, Boston, MA, U.S.A.,
3Wake Forest Baptist Medical Center, Winston-Salem, NC, U.S.A., 4Brigham and Women's Hospital, Boston, MA, U.S.A.
from Jules: Not surprisingly smoking increased risk, see Table 3 for all risk factors.
Program abstract: The relative increase in stroke rates in HIV-infected women was most pronounced among younger women (18-35 years, IRR 4.96, 95% CI 1.58-13.52; 36-45 years, IRR 3.78, 95% CI 1.63-8.10; 46-55 years, IRR 2.60, 95% CI 1.25-5.03). HIV was significantly associated with increased stroke risk in univariate models (hazard ratio [HR] 2.43, 95% CI 1.78-3.61) and in models adjusting for demographics and vascular risk factors (HR 1.81, 95% CI 1.26-2.61). In a multivariable model further adjusted for sex-specific risk factors (menopause/vasomotor symptoms, premature ovarian failure, hormone replacement therapy/oral contraceptive use, pregnancy, pre-eclampsia/eclampsia, migraine, and depression/anxiety), the greater hazard of stroke associated with HIV persisted (HR 2.14, 95% CI 1.45-3.15).
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