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Hepatitis C and the Risk of Non-Liver-Related Morbidity
and Mortality in HIV+ Persons....kidney, bone, cardiovascular
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from Jules: IDU and hcv have been found in other studies to be associated with contributing to kidney disease.
Reported by Jules Levin
CROI 2016 Feb 22-24 Boston
Helen Kovari1; Rainer Weber1; Alexandra L. Calmy2; Matthias Cavassini3; Marcel Stoeckle4; Patrick Schmid5; Enos Bernasconi6; Andri Rauch7; Bruno Ledergerber1; for the Swiss HIV Cohort Study
1Univ Hosp Zurich, Zurich, Switzerland;2Univ Hosp Geneva, Univ of Geneva, Geneva, Switzerland;3Univ Hosp Lausanne, Univ of Lausanne, Lausanne, Switzerland;4Univ Hosp Basel, Basel, Switzerland;5Cantonal Hosp, St Gall, Switzerland, St. Gall, Switzerland;6Regional Hosp Lugano, Lugano, Switzerland;7Bern Univ Hosp and Univ of Bern, Bern, Switzerland
from Jules: HCV increased risk for kidney (2.4 times increased risk), liver, bone, cardiovascular events, liver-related deaths (8.4 times increased risk, and deaths; achieving SVR vs non achieving SVR reduced the risk for kidney disease on average from a 3.6 times increased risk by 200% to almost normal [1.2 times risk] see Figure 3, SVR vs no SVR reduced risk for cardiovascular disease by 100%, and of course liver disease and death (Table 2):
"After a mean follow-up of 8.2 years we observed the following events for HCV-seropositive/HCV-seronegative patients: 107/18 liver events, 41/14 kidney events, 230/121 osteoporosis/fractures, 114/129 cardiovascular diseases, 162/126 HIV CDC B/C events, 106/10 liver-related deaths, and 227/218 non-liver-related deaths. Incidence rates per 1000 person-years are shown in Table 3."
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