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Depression and Social Isolation Mediate Effect of
HIV Stigma on Women's ART Adherence
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"findings suggest that potential predictors of adherence may operate differently by race.....contribute to our understanding of different rates of adherence and health outcomes by race among women living with HIV.....also suggest that interconnected psychosocial mechanisms affect ART adherence.....internalized stigma was a significant predictor of sub-optimal adherence....Predictors of better adherence included non-Hispanic white race/ethnicity, older age, less years on ART, and nonuse of non-injection drugs.....the association between internalized stigma and adherence was significant for those in racial and ethnic minority groups.....Depressive symptoms, loneliness, and low perceived social support mediated the association between internalized stigma and sub-optimal adherence in the whole sample, as well as in the subsample of minority participants.....internalized stigma predicted less perceived social support (or higher loneliness), which in turn predicted more depressive symptoms, which in turn predicted suboptimal medication adherence."
Reported by Jules Levin
CROI 2015 Feb 22-24 Boston
Bulent Turan, PhD,1 Whitney Smith, MPH,1 Mardge H. Cohen, MD,2 Tracey E. Wilson, PhD,3 Adaora A. Adimora, MD,4 Daniel Merenstein, MD,5 Adebola Adedimeji, PhD, MPH, MBA,6 Lisa Metsch, PhD,7 Sheri D. Weiser, MD, MPH,8
Janet M. Turan, PhD, MPH 1
1 University of Alabama at Birmingham; 2 Stroger Hospital; 3 State University of New York Downstate; 4 University of North Carolina at Chapel Hill; 5 Georgetown University; 6 Albert Einstein College of Medicine; 7 Columbia University; 8 University of California, San Francisco
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