icon-folder.gif   Conference Reports for NATAP  
 
  17th International Workshop
on Clinical Pharmacology of
HIV and Hepatitis Therapy
June 8-10, 2016, Washington DC
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Phosphoramidate prodrugs of uridine analogs, including sofosbuvir, are metabolized to both uridine and cytidine triphosphates in Huh7 cells and primary human hepatocytes
 
 
  Reported by Jules Levin
 
17th International Workshop on Clinical Pharmacology of HIV and Hepatitis Therapy, June 8-10, 2016, Washington DC
 
R. Bethell1, A. Lindqvist1, S. Juric1, C. Rydergard1, H. Westerlind1, A. Eneroth1, K. Wikstrom1, H. Kylefjord1, G. Kalayanov1, E. Lindström1, P. Targett-Adams1, P. Pinho1, A. Rosenquist1
 
1Medivir AB, R&D, Huddinge, Sweden

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References:
 
1. MJ Sofia et al., J. Med. Chem. (2010), 53, 7202-7218;
 
  2. 2. FDA review documentation (accessed May 29th 2016):
http://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/204671Orig1s000PharmR.pdf