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HCC DEVELOPMENT IN HCV PATIENTS AFTER DAA: THE EXPERIENCE OF THE SCOLTA PROJECT
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....'delaying treatment increases risk for HCC: increased risk of almost 5-fold if patient is F4 vs F0-3'
patients, either HCVmono- or HIV/HCV connected who started DAA treatment. For HCV treatment and HCC surveillance, patients were followed according to Italian guidelines.....Twenty-seven patients developed HCC,as a first diagnosis in 21 cases and recurrence in 6....Twenty-seven patients developed HCC, as a first diagnosis in 21 cases and recurrence in 6....In a multivariate Cox model including age, sex, Metavir, HIVco-infection, HCV genotype, and outcome at 12 weeks, age (HR1.06,95%CI1.01-1.12, by 1year) and Metavir F4 (HR 4.70, 95% CI 1.08-20.44 as compared to F0-F3) were significantly associated to HCC (Figure3)
Reported by Jules Levin
CROI 1017 Feb 14-16 Seattle, WA
B.Menzaghi1,C.Magni2,L.Nicolini3,G.Cenderello4,VitoFiore5,M.Gussio6,R.Gulminetti7,F.Vichi8,P.Bonfanti9
1 Unit of Infectious Diseases, ASST Valle Olona-Busto Arsizio2 Department of Infectious Diseases, ASST Fatebenefratelli-Sacco 3 Infectious Diseases, San Martino Hospital Genoa, University of Genoa
4 Unit of Infectious Diseases, GallieraHospital,Genoa5 Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy 6 Unit of Infectious Diseases, Garibaldi Hospital, Catania, Italy7 Department of Infectious Diseases, IRCCS PoliclinicoSan Matteo Foundation university of Pavia, Pavia8 Unit of Infectious Diseases, Santa Maria Annunziata Hospital, Firenze9 Unit of Infectious Diseases, A. Manzoni Hospital, Lecco
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