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Changes in Liver Fibrosis and Steatosis in HIV Mono-Infected
patients over 24 months - 50% have fatty liver at average age of 46
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Reported by Jules Levin
CROI 2017 Feb 14-16 Seattle, WA
"Significant fibrosis and hepatic steatosis are highly prevalent among HIV mono infected patients.At baseline 41% of the patients had significant steatosis (CAP > 238 dB/m) vs. 54% of the patients after 24 months (p = 0.023)"
from Jules: there is no doubt to me that the old nukes - AZT, ddI, d4T - caused fatty liver. HIV itself causes fatty liver, which was found in this study, and unsuppressed viral load & low nadir CD4 contribute to fatty liver. The metabolic syndrome caused by HIV which persists depute suppressed HIV & high CD4s I am sure contributes to fatty liver. Again, diet & exercise are important, but more important is to pay greater attention to this health hazard particularly as HIV patient population ages. There are no really reliable biomarkers so more research is needed. But fatly liver, hepatic steatosis can cause severe liver disease & fibrosis, this needs more attention in HIV because we still do not have much data on the contribution of each ART & class, ARTs used in this modern era.
Raphael Mohr1,2, Christoph Boesecke1,2, Carolynne Schwarze-Zander1,2, Jan-Christian Wasmuth1,2, Jonel Trebicka1, Jurgen Kurt Rockstroh1,2
1Bonn University Hospital, Bonn, Germany; 2) German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, Germany
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