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Longitudinal HIV Viral Trajectories and Co-Morbidities Longitudinal in the WIHS: Viral Suppression Key to Survival
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Reported by Jules Levin
CROI 2017 Feb 14-17 Seattle, WA
from Jules: in Figure 1 you see only 29% were non-viremic, 29% with intermittent viremia and 41% with sustained viremia ...."Long term viral suppression key to survival, but risk factors for cardiovascular disease greater on HAART"
"On multivariate analysis, individuals with AIDS defining conditions and AIDS-associated cancers were more likely to have sustained viremia .....Compared to women with sustained viremia, women with viral suppression were more likely (HR 1.4, p=0.0072) to report risk factors for cardiovascular disease (hypertension, hyperlipidemia, diabetes), without concurrent increased risk of cardiovascular disease outcomes" from Jules: perhaps long term viral suppression reduces inflammation but risk factors like lipids etc may be greater on HAART.
Seble Kassaye1, Cuiwei Wang1, Jeff Collmann2, Tracey Wilson3, Kathryn Anastos4, Mardge Cohen5, Ruth M Greenblatt6, Joel Milam7, Stephen Gange8, Michael Plankey1
1Georgetown University Medical Center, Washington, DC, USA. 2The Office of the Senior Vice President for Research, Georgetown University, Washington DC, USA;3 State University of New York, Downstate Medical Center, Brooklyn, NY, USA, 4 Albert Einstein College of Medicine and Montefiore Health Systems, New York, NY, United States, 5 Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL, USA; 6UCSF Schools of Pharmacy and Medicine, San Francisco, CA, USA, 7;
Keck School of Medicine, University of Southern California, CA, USA; 8Johns Hopkins University, Baltimore, MD, USA
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