icon-    folder.gif   Conference Reports for NATAP  
 
  Conference on Retroviruses
and Opportunistic Infections (CROI)
February 13-16, 2017, Seattle WA
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New HIV Drugs at CROI / CROI Antiretroviral
Treatment Summary / Long Acting HIV Therapies
 
 
  CROI: CROI Summary 2017: Antiretroviral treatment - where we are now / New HIV Drugs & Treatments - Joseph J. Eron MD Professor of Medicine University of North Carolina at Chapel Hill - (03/06/17)
 
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CROI 2017 - Conference on Retroviruses and Opportunistic Infections (CROI) February 13-16, 2017, Seattle WA
 
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CROI: SWORD 1 & 2: Switch to DTG + RPV Maintains Virologic Suppression Through 48 Weeks, a Phase III Study - (02/16/17)
 
CROI: Doravirine in Non-Inferior To Darunavir+Ritonavir in Phase 3 Treatment-Naive Trial at Week 48 - (02/16/17)
 
CROI: Randomized Trial of Bictegravir or Dolutegravir with FTC/TAF for Initial HIV Therapy - (02/16/17)
 
CROI: New Integrase Inhibitor Attains 97% Viral Suppression Through 48 Weeks - written by Mark Mascolini - (02/15/17)
 
CROI: Bictegravir Dissociation Half-life from HIV-1 G140S/Q148H Integrase-DNA Complexes - (02/28/17)
 
CROI: Clinical Pharmacology of the Unboosted HIV Integrase Strand Transfer Inhibitor (INSTI) Bictegravir (BIC) - (02/16/17)
 
CROI: PRO 140 Single-Agent Maintenance Therapy for HIV-1 Infection: A 2-Year Update - (03/01/17)
 
CROI: LONG-ACTING IBALIZUMAB IN PATIENTS WITH MULTI-DRUG RESISTANT HIV-1: A 24-WEEK STUDY - (02/16/17)
 
CROI: Theratechnologies Announces New Data from the Pivotal Phase III Trial of HIV Monoclonal Antibody and Long-Acting Investigational Antiretroviral Ibalizumab - (02/16/17)
 
CROI: Discovery of Novel Potent HIV Capsid Inhibitors with Long-Acting Potential - (02/16/17)
 
CROI: Promising Results of Lamivudine + Dolutegravir Maintenance Therapy in ANRS 167 Lamidol Trial - (02/23/17)
 
CROI: Dolutegravir as Maintenance Monotherapy for HIV-1: a Randomized Clinical Trial - (02/23/17)
 
CROI: Novel HIV PI with High Resistance Barrier and Potential for Unboosted QD Oral Dosing - (02/28/17)
 
CROI: MK-8591 Concentrations at Sites of HIV Transmission and Replication - (02/23/17)
 
CROI: GS-9131 is a Novel NRTI with Activity Against NRTI-Resistant HIV-1 - (02/23/17)
 
CROI:
Antiviral Activity of EFdA [MK-8591] Against NRTI-Sensitive and -Resistant Strains of HIV-2 - (02/24/17)
 
GLASGOW: HIV Combinectin GSK3732394: A Long-Acting Inhibitor With Multiple Modes of Action - (10/30/16)
 
CROI: Long-Term Efficacy of Dolutegravir 50 mg BID in INI-Resistant Failing HIV-1 Subjects - (02/16/17)
 
CROI: HIV Attachment Inhibitor Fostemsavir / BMS-663068, GSK3684934 - (02/16/17)
 
CROI: HIV Integrase Genotypic Testing and Resistance in the United States-9 U.S. Jurisdictions - (02/22/17)
 
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Long-Acting & Nanoparticle ARTs - Future of HIV Medication???
 
Jules Levin, NATAP
 
New nano approach could cut dose of leading HIV treatment in half University of Liverpool
 
https://news.liverpool.ac.uk/2017/02/17/new-nano-approach-to-hiv-therapy-presented-at-leading-conference/

 
Long acting Cabotegravir for PrEP is in Phase 3 so this is the closest in terms of reality, for a major impact of long-acting drugs with a potential to impact HIV & AIDS, but in the area of PrEP. Increasingly over the past few years we have been hearing about nano technology and about implants which would be long acting and have the added characteristic that the implant could be removed at any time, this helps regarding if adverse events occur related to the drug in question.
 
HPTN 083 & HPTN 084 [for women] https://www.hptn.org/research/studies/176 https://www.niaid.nih.gov/news-events/nih-launches-first-large-trial-long-acting-injectable-drug-hiv-prevention A Phase 2b/3 Double Blind Safety and Efficacy Study of Injectable Cabotegravir Compared to Daily Oral Tenofovir Disoproxil Fumarate/Emtricitabine (TDF/FTC), for Pre-Exposure Prophylaxis in HIV-Uninfected Cisgender Men and Transgender Women who have Sex with Men..... https://www.hptn.org/sites/default/files/2016-06/(T5) Raphael Landovitz - FINAL v2 (6.14.2016)_0.pdf
 
CROI: A LONG-ACTING NANOFORMULATED CABOTEGRAVIR PRODRUG FOR IMPROVED ANTIRETROVIRAL THERAPY - (02/23/17)
 
Liverpool CROI presentation - CROI: HUMAN CONFIRMATION OF ORAL DOSE REDUCTION POTENTIAL OF NANOPARTICLE ANTIRETROVIRAL FORMULATIONS - (03/02/17)
 
CROI: Long Acting HIV ART - is this the future? Nanoformulations - Implants - (03/02/17)
 
CROI: Long-term Safety and Efficacy of CAB and RPV as 2-Drug Oral Maintenance Therapy - (02/18/17)
 
CROI16: ECLAIR: Phase 2A Safety and PK Study of Cabotegravir LA in HIV-Uninfected Men.......Long-Acting Cabotegravir Data Suggest PrEP Injections Every 8 Week
 
CROI: ViiV Healthcare announces first phase II HIV prevention study results for investigational long-acting injectable cabotegravir - (02/29/16)
 
CROI: In Vitro -In Vivo Evaluation of a Biodegradable Implant Containing TAF for HIV PrEP - (02/16/17)
 
CROI: Discovery of Novel Potent HIV Capsid Inhibitors with Long-Acting Potential - (02/16/17)
 
CROI: LONG-ACTING IBALIZUMAB IN PATIENTS WITH MULTI-DRUG RESISTANT HIV-1: A 24-WEEK STUDY - (02/16/17)
 
CROI: Theratechnologies Announces New Data from the Pivotal Phase III Trial of HIV Monoclonal Antibody and Long-Acting Investigational Antiretroviral Ibalizumab - (02/16/17)
 
CROI:
PRO 140 Single-Agent Maintenance Therapy for HIV-1 Infection: A 2-Year Update - (03/01/17)
 
CROI: Antiviral Activity of EFdA [MK-8591] Against NRTI-Sensitive and -Resistant Strains of HIV-2 - (02/24/17)
 
CROI: MK-8591 Concentrations at Sites of HIV Transmission and Replication- (02/23/17)