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EXERCISE, OXIDATIVE STRESS AND FIBRINOLYTIC
FUNCTION IN HIV-1 INFECTED ADULTS
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"In non-HIV-1-infected populations, regular aerobic exercise is arguably the most effective non-pharmacological intervention for reducing CVD morbidity and mortality."....from Jules: exercise also reduces inflammation, improves cognitive function, improves diabetes glucose levels control, reduces blood pressure
Reported by Jules Levin
CROI 2017 Feb 14-17 Seattle WA
Elizabeth Connick, Jared J. Greiner, Caitlin A. Dow, Kyle J. Diehl, Brian L. Stauffer and Christopher A. DeSouza
Departments of Medicine and Integrative Physiology
University of Arizona, Tuscon AZ, University of Colorado, Boulder and Denver, CO
III. 12 weeks of aerobic exercise training significantly increased the capacity of the endothelium to release t-PA in HIV-1-seropositive adults. Net release (A) and total amount (area under the curve: B) of t-PA antigen were ∼85% higher after compared with before exercise training. *P<0.05
There was no effect of SNP on endothelial fibrinolytic function before or after exercise training (data not shown).
IV. Before exercise training, the co-infusion of vitamin C with bradykinin significantly increased (∼100%) endothelial t-PA release. After exercise training, the co-infusion of vitamin C did not signifcantly affect t-PA release. *P<0.05
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