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Treatment with Selonsertib, an Inhibitor of Apoptosis Signal-Regulating Kinase 1 (ASK1), Reduces Hepatic Phospho-p38 Expression and Markers of Hepatocellular Apoptosis and Necrosis in Patients with NASH
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Reported by Jules Levin
EASL 2017 April 19-23 Amsterdam Netherlands
Anna Mae Diehl,1 Dorothy M. French,2 Ren Xu,2 Rohit Loomba,3 Eric Lawitz,4 Bradley Freilich,5 Mitchell L. Shiffman,6 Naga Chalasani,7 Bilal Hameed,8 Stephen Caldwell,9 Mary Rinella,10 Matt Peach,2 Erik Huntzicker,2 Scott Turner,2 Ted Sullivan,2 Guang Chen,2 C. Stephen Djedjos,2 Robert P. Myers,2 G. Mani Subramanian,2 Zachary Goodman,11 Claude Sirlin,3 Michael Charlton,12 Nezam H. Afdhal13
1Duke Clinical Research Institute, Durham, NC, USA; 2Gilead Sciences, Inc., Foster City, CA, USA;3University of California San Diego, La Jolla, CA, USA; 4Texas Liver Institute, University of Texas Health, San Antonio, TX, USA; 5Kansas City Research Institute, Kansas City, MO, USA; 6Liver Institute of Virginia, Newport News, VA, USA; 7Indiana University School of Medicine, Indianapolis, IN, USA; 8University of California San Francisco, San Francisco, CA, USA; 9University of Virginia, Charlottesville, VA, USA; 10Northwestern Memorial Hospital, Chicago, IL, USA; 11Inova Fairfax Hospital, Falls Church, VA, USA; 12Intermountain Medical Center, Salt Lake City, UT, USA; 13Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
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