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Alterations in oral microbiota in HIV-infected individuals related to pulmonary function
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"we can conclude the oral microbiome was altered in HIV+ individuals with abnormal lung function, but not in HIV- individuals. This indicates oral microbiome plays a unique role in the pathogenesis of chronic lung diseases in HIV."
"Abnormal lung function is associated with certain bacteria.
Linear discriminant analysis effect size (LEfSe) was used to identify genera that were significantly differentially abundant between individuals with or without abnormal lung function.
From this - figure -see below-, we can see, in HIV-infected group, increased … and decreased were associated with abnormal lung function.
Maybe these bacteria can be used as biomarkers of lung dysfunction in HIV
It has been reported that certain species of veillonella and streptococcus are associated with inflammation, and high abundance of lactobacillus was seen in patients with poor dental healthy. But more studies are needed to investigate the underlying mechanisms."
"Taken together, we think HIV infection and associated immune suppression, ART, smoking change oral microbiome. Oral microbiome enters the lung via aspiration and dispersion. Altered oral microbiome, lung microbiome and associated changes in metabolism and immune responses lead to lung damage.
Perhaps we can target relevant oral bacteria and associated inflammation as intervention in HIV COPD"
"Gut microbiome regulates the body's entire immune responses, and dysbiosis in the gut microbiota can lead to diseases in extraintestinal organs including the lung via systemic immunity"
Reported by Jules Levin
20th International Workshop on Comorbidities and Adverse Drug Reactions in HIV
Libing Yang, MDc
Mentor: Alison Morris, MD, MS
Division of Pulmonary, Allergy and Critical Care Medicine
Center for Medicine and the Microbiome
University of Pittsburgh, Pittsburgh, PA
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