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ACC Inhibitor Demonstrates Potent Antifibrotic Activity In Vitro and In Vivo
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Reported by Jules Levin
EASL 2018 April 11-15 Paris France
Jamie Bates,1 Sarani Ghoshal,2 Lan Wei,2 David Hollenback,1 Kathy Liu,1 Saritha Kusam,1 Maisoun Sulfab,1 Henry Liu,1 Robert Brockett,1* David Newstrom,1 Igor Mikaelian,1* Ting Wang,1 Geraldine Harriman,3 William F. Westlin,3 Jennifer Rocnik,3 H. James Harwood,3 Rosana Kapeller,3* Bryan C. Fuchs,2 Adrian S. Ray,1 David G. Breckenridge1
1Gilead Sciences, Inc., Foster City, California, USA; 2Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; 3Nimbus Therapeutics, Cambridge, Massachusetts *Formerly employed.
References
1. Abu-Elheiga L, et al. Proc Natl Acad Sci USA 2005;102:12011-6; 2. Mao J, et al. Proc Natl Acad Sci USA 2006;103:8552-7; 3. Harriman G, et al. Proc Natl Acad Sci USA 2016;113:E1796-805; 4. Lawitz EJ, et al. EASL 2017, abstr LBO-002; 5. Loomba R, et al. AASLD 2017, abstr LB-9.
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