Amprenavir and Hi-Fat Meals

There have been questions about taking amprenavir with a "hi fat" meal.

With very high fat, ~67 grams, there is a slight reduction - ~20%- in
plasma concentration of amprenavir.. This is not a normal amount of fat in a
meal which is why the package insert states that "Agenerase may be taken with
or without food, however, a high fat meal decreases the absortion of
amprenavir and
should be avoided" The meal we used for the "high fat" study was 3 fried
eggs, bacon, toast with butter, cereal with whole milk.