In
Vitro Synergy of Abacavir and Mycophenolic Acid
Mycophenolic
acid (MA) is currently used in organ transplantation. Using it in combination
with abacavir appears to provide a similar synergy to that hydroxyurea provides
for ddI. DM Margolis with the University of Baltimore Institute of human
Virology in Baltimore reported at ICAAC that in vitro, MA with abacavir was
potent and synergistic. MA combined with AZT or d4T was antagonistic. The amount
of MA needed may be at a reduced dose than used in organ transplant thus
possibly reducing potential for toxicity. Margolis reported that viruses with
the 3TC M184V mutation displayed sensitivity to abacavir comparable to wild-type
HIV. Viruses with abacavir mutations are being studied.