Study 903Conclusions

• Among virologic failures at week 48, the genotype at last failure time point showed most commonly EFV resistance (4.7%), wild-type (3.6%), or M184V (3.3%)

  • K103N most common EFV-R mutation
  • no significant differences between treatment arms

• K65R emerged less frequently in both arms

  • 7/299 patients (2.3%) in TDF arm
  • 2/301 patients (0.7%) in the d4T arm
  • observed only with EFV resistance
  • viral load at virologic failure with K65R maintained mean 0.9 log10 decrease from baseline

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