ReutersBig.gif  
Back grey_arrow_rt.gif
 
 
Minor HIV protease mutations point to antiretroviral failure
 
 
  By David Douglas
 
NEW YORK (Reuters Health) - Minor mutations of 36I and 101/V in HIV protease can predict the appearance of a mutation associated with resistance to protease inhibitors (PIs), European researchers report in the June 1st issue of the Journal of Infectious Diseases.
 
Dr. Carlo Federico Perno of the University of Rome Tor Vergata and colleagues, who note that 36I is seen in about 25% of HIV clade B and more than 80% of non-clade B viruses, came to this conclusion after studying 93 previously drug-naive patients who experienced failure of their first PI -based antiretroviral regimens.
 
The 90M primary mutation is associated with different levels of resistance to all current PIs, say the investigators, and identifying factors associated with its appearance "is particularly relevant from the clinical standpoint."
 
The findings, Dr. Perno told Reuters Health, could be eventually used in developing therapeutic strategies as well as "implementation of the diagnostic algorithms that are used in clinical practice for a better utilization of the inhibitors of HIV replication."
 
He and his colleagues conclude that if their results are confirmed, "use of resistance testing in chronically-infected drug naive patients before initiation of therapy should become the rule."
 
J Infect Dis 2004;189:1983-1987.
 

 

 
Copyright © 2004 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.
 
 
 
 
  icon paper stack View Older Articles   Back to Top   www.natap.org