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Hepatitis C infection is not associated with systemic HIV-associated non-Hodgkin's lymphoma: a cohort study
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Reported by Jules Levin
IAS-Rio July 2005
Poster TuPe1.1C09
Waters L.1, Stebbing J.1, Mandalia S.1, Young A.-M.1, Nelson M.1, Gazzard B.1, Bower M.1
1Chelsea & Westminster Hospital, London, United Kingdom
ABSTRACT
Introduction: HIV-associated immunosuppression increases the risk of non-Hodgkin's lymphoma (NHL). The hepatitis C virus (HCV) has been
implicated in the development of B cell lymphomas, and HCV is common in HIV-infected individuals, we compared the incidence of systemic NHL during
HIV infection compared with HIV and HCV co-infection.
Methods: Data were extracted from a prospectively collected database for all patients entering our cohort in the HAART era. To compare lymphoma risk
in HIV mono-infected and co-infected individuals, person years at risk (PYAR) was estimated from cohort entry to i) end of study period, ii) NHL
development, iii) last recorded visit or iv) date of death. Data were analysed using the Genmod with loge link and Poisson error distributions; all p values
are two-sided. All NHL cases were biopsy-proven and primary CNS lymphomas were excluded.
Results: Out of 5,832 individuals studied during the era of highly active anti-retroviral therapy (HAART), 102 patients were diagnosed with systemic NHL.
The incidence of systemic NHL was 6.9/ 104 patient years in co-infected individuals compared with 7.1/ 104 patient years if HIV mono-infected (p = 0.9).
Conclusions: In this immunocompromised patient population, there was no association between HCV infection and an increased risk of lymphoma.
ED NOTE from Jules Levin: this is an important question and so we need better designed studies to tease out the possibility that HCV & HIV may cause higher rates of NHL in certain HIV+ patient populations.
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