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Updated Perinatal Guidelines by the DHHS
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On October 12, the Public Health Service Task Force updated its Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States.
Postpartum Hemorrhage, Antiretroviral Drugs, and Methergine Use. "Methergine should not be co-administered with drugs that are potent CYP3A4 enzyme inhibitors, including protease inhibitors and the NNRTIs efavirenz and delavirdine...."
An Update on Preconceptual Counseling and Care for HIV-1-Infected Women of Childbearing Age. It is recommended that all women of child-bearing age are offered the opportunity to receive preconception counseling and care as a component of routine primary medical care.
Kaletra was added as a first-line preferred PI in HIV+ women who are pregnant; prior to this update Viracept was the only preferred PI. There is an update on abacavir; in Table 3, "pharmacokinetics are not significantly altered in pregnancy; no change in dose is indicated". The Guidelines are updated with information on the use of Darunavir (TMC114). In addition, there is an update on Kaletra: in Table 3, "pharmacokinetic studies of standard dose of lopinavir/ritonavir capsules a (3 capsules twice daily) during 3rd trimester indicated levels were significantly lower than during postpartum period and in non-pregnant adults; an increased dose of 4 capsules of lopinavir/ritonavir twice daily starting in the 3rd trimester resulted in adequate lopinavir exposure; by 2 weeks postpartum, standard dosing was again appropriate. Pharmacokinetic studies of the new lopinavir/ritonavir tablet formulation are underway, but data are not yet available." And there is additional information in the Guidelines.
Here are the documents for you to download:
Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women in PDF
Safety and Toxicity of Individual Antiretroviral Agents in Pregnancy in PDF
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