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HIV Infection and the Risk of Diabetes Mellitus
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Reported by Jules Levin
ICAAC/IDSA Oct 28 2008 Wash DC
A. A. BUTT1, K. MCGINNIS 2, M. RODRIGUEZ-BARRADAS 3, S. CRYSTAL 4, M. SIMBERKOFF 5, M. GOETZ 6, D. LEAF 6, A. JUSTICE 7;
1Univ. of Pittsburgh, Pittsburgh, PA, 2VA Pittsburgh Hlth.care System, Pittsburgh, PA, 3Michael E. DeBakey VA Med. Ctr., Houston, TX, 4Rutgers Univ.,, New Brunswick, NJ, 5New York VA Med. Ctr., New York, NY, 6VA Greater Los Angeles Hlth.care System, Los Angeles, CA, 7VA Connecticut Hlth.care System, West Haven, CT.
Abstract:
Background: Role of HIV upon the risk of diabetes is uncertain.
Methods: We studied 3,327 HIV-infected and 3,240 HIV-uninfected subjects, enrolled in the Veterans Aging Cohort Study (VACS). We determined the presence of, and factors associated with diabetes in each group at baseline.
Results: HIV infected subjects were younger, more likely to be black race, male, and have HCV coinfection and had a significantly lower BMI, and had less use of alcohol but more drug use.
In multivariable analysis, HIV was still associated with a lower risk of DM (OR 0.84, 95% CI 0.72-0.97).
Increasing age, male gender, minority race, and BMI were associated with an increased risk, while increasing amount of alcohol use and a history of drug abuse or dependence were associated with a lower risk of DM.
The effect of increasing age, minority race and BMI were more pronounced in the HIV infected group.
HCV coinfection was associated with a higher risk of DM in the HIV infected, but not in the HIV uninfected group.
Conclusion: In this prospective, observational cohort, HIV was associated with a lower risk of diabetes even after adjusting for traditional risk factors.
* not included in the model, since HIV uninfected subjects were included
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