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Association between HBV Replication and Serum ALT Changes is not Dependent on HBV Genotype and Mutants
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Digestive Disease Week 2009 McCormick Place, Chicago Illinois May 30-June 4, 2009
Reported by Jules Levin
Hwai-I Yang1,2, Uchenna H Iloeje3, Jun Su3, Chin-Lan Jen1,2, San-Lin You1,2 and Chien-Jen Chen1,2 for the R.E.V.E.A.L.-HBV Study Group
1Genomics Research Center, Academia Sinica, Taipei, Taiwan; 2Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan; 3Research and Development, Bristol-Myers Squibb Company, Wallingford, USA
Author Summary
A total of 320 (37.5%) subjects had at least one ALT elevation (≥45 U/L) during follow-up
Male gender, baseline serum ALT and HBV DNA levels were statistically significantly associated with future ALT elevation
Serum HBV DNA level was the strongest predictor of ALT elevation during long term follow-up
HBV genotype, precore G1896A and BCP A1762T/G1764A mutations were not statistically associated with ALT elevation
The association between serum HBV DNA level and ALT elevation still holds when stratifying by HBV genotype, precore and BCP mutations
Author Conclusions
High viral load remained the most important risk factor for ALT elevation regardless of genotype, precore and BCP mutations
Lowering serum HBV viral load might be the key to prevent future elevation of ALT level
References
1. Chen CF, Yang HI, Iloeje UH, et al. Changes in serum HBV DNA level using a trajectory model to predict the risk of HCC in chronic hepatitis B patients: the R.E.V.E.A.L-HBV study. 18th APASL meeeting, March 23-26, 2008.
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