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Increasing incidence of ischemic stroke in patients with HIV infection: HIV, HAART, metabolics, median age 50, absolute numbers small - pdf attached
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Over the study period from 1997 through 2006, the total primary stroke diagnoses in the United States generally declined (7.2% relative drop) in 2006 compared to 1997 (table 1). However, total primary stroke diagnoses among persons with comorbid HIV infection generally rose (table 1), with 537 more incident strokes (60.5% relative rise) in 2006 compared to 1997 (trend for change in proportion: p <0.0001)....'due to perhaps to direct affect of longer exposure to HIV'...'HAART directly causes immune activation, metabolic/endothelial dysfunction that can accelerate atherosclerosis9-11 and lead to symptomatic ischemic vascular events'.....'mild liver disease had by far the strongest association. It is possible that the hepato-renal dysfunction may contribute to the metabolic syndrome leading to accelerated vascular disease. Also supporting this notion is the change in the demographics over time, with older, male, and African American subjects encountered later in the study period'..... the absolute numbers of stroke hospitalizations with HIV infection are relatively small, reflecting the fact that stroke is generally an infrequent manifestation of HIV infection, this steep rise over a short period of time may be of major public health concern......The median age for stroke in this population was the fifth decade (50 yrs old patients age), which is much lower than that of the non-HIV-infected population. This indicates that HIV infection or its treatment is directly related to the stroke pathophysiology in this population......observed increase in several metabolic factors over time may have predisposed these patients to greater risk for developing strokes. It is also possible that recently there has been greatly increased action by the virus in facilitating these mechanisms to the extent that ischemic stroke incidence in particular is much higher, but this would seem unlikely without any supportive evidence......increased stroke among HIV+ "is coupled with an increase in patients on Medicaid and a decrease in those on private insurance, which has important socioeconomic consequences.....the proportion of patients hospitalized for ischemic stroke with comorbid HIV infection more than doubled by 2006, and it appears that the first major uptick began about midyear of 2001......Also in Table 2 you can see urban nonteaching hospitals and Medicaid vs private care associated with increased rates of stroke among HIV+
Neurology; Prepublished online January 19, 2011
Neurology is the official journal of the American Academy of Neurology
from Jules: in Table 3 Mild Liver Disease is associated with a 6.38 Odds Ratio for increased stroke after adjusted analysis. If you look at table 2 patients with HIV & stroke had higher rates of hypertension, diabetes without complications, dementia, chronic pulmonary disease, liver disease, renal disease.
"HIV infection can cause stroke via several mechanisms including HIV-stimulated endothelial activation (predisposing to accelerated atherosclerosis).....and metabolic derangements..... the observed increase in several metabolic factors over time may have predisposed these patients to greater risk for developing strokes. It is also possible that recently there has been greatly increased action by the virus in facilitating these mechanisms to the extent that ischemic stroke incidence in particular is much higher, but this would seem unlikely without any supportive evidence......longer exposure to HIV, even at low viral load levels, may allow for the direct effects of the virus to increase stroke risk. Second, combination antiretroviral therapy directly causes immune activation and metabolic and endothelial dysfunction that can accelerate atherosclerosis9-11 and lead to symptomatic ischemic vascular events.12,13 Third, hepatotoxicity is a known complication of combination antiretroviral drug treatment,14 and in our multivariable analyses among factors independently linked to coexistent HIV infection with stroke hospitalization, mild liver disease had by far the strongest association. It is possible that the hepato-renal dysfunction may contribute to the metabolic syndrome leading to accelerated vascular disease......Also supporting this notion is the change in the demographics over time, with older, male, and African American subjects encountered later in the study period. Each of these demographic factors could independently increase the rate of stroke alone and account for some of the observed differences"
"A better understanding of the evolving occurrence of stroke in HIV-infected patients, especially on a nationwide level, could raise awareness and open up avenues for curbing this major neurologic complication of HIV......Over the study period, the weighted number of total primary stroke diagnoses in the United States generally declined, with 71,742 fewer incident strokes (7.2% relative drop) in 2006 compared to 1997 (table 1). However, total primary stroke diagnoses among persons with comorbid HIV infection generally rose (table 1), with 537 more incident strokes (60.5% relative rise) in 2006 compared to 1997 (trend for change in proportion: p <0.0001)......even after adjustment for population size, following an initial period of decline prior to 2001 there was a roughly 43% increase in the rate of stroke hospitalizations in the HIV+ US population after 2001 from 90 hospitalizations per 100,000 persons in 2001 to 129 hospitalizations per 100,000 persons in 2006 (p = 0.02)...."
"boost in proportion of patients hospitalized for stroke with prevalent HIV infection was not driven by recently recognized reductions in stroke incidence due to traditional vascular risk factor control, but possibly by evolving circumstances unique to HIV- infected patients.....Although the absolute numbers of stroke hospitalizations with HIV infection are relatively small, reflecting the fact that stroke is generally an infrequent manifestation of HIV infection, this steep rise over a short period of time may be of major public health concern. This is coupled with an increase in patients on Medicaid and a decrease in those on private insurance, which has important socioeconomic consequences.....he proportion of patients hospitalized for ischemic stroke with comorbid HIV infection more than doubled by 2006, and it appears that the first major uptick began about midyear of 2001."
"The precise reasons for the rise in patients hospitalized for stroke with coexisting HIV infection are not immediately clear and are beyond the scope of this administrative dataset to decipher. However, there are some speculations that could be made based partly on these results as well as prior knowledge. The median age for stroke in this population was the fifth decade (50 yrs old patients age), which is much lower than that of the non-HIV-infected population. This indicates that HIV infection or its treatment is directly related to the stroke pathophysiology in this population. HIV infection can cause stroke via several mechanisms including HIV-stimulated endothelial activation (predisposing to accelerated atherosclerosis), opportunistic infections, neoplasia, HIV-induced cardiac disease, HIV-associated cerebral vasculopathy, HIV-induced systemic vasculitis, prothrombosis, and metabolic derangements.4-8 So for instance, the observed increase in several metabolic factors over time may have predisposed these patients to greater risk for developing strokes. It is also possible that recently there has been greatly increased action by the virus in facilitating these mechanisms to the extent that ischemic stroke incidence in particular is much higher, but this would seem unlikely without any supportive evidence."
"A more plausible explanation could be that these trends reflect consequences of broad use of combination antiretroviral therapies in HIV-infected patients. First, combination antiretroviral therapy increases life expectancy and as such inadvertently boosts the risk of ischemic stroke, a condition that is highly age-correlated and occurs with greater length of time exposure to conventional vascular risk factors.1 In fact, the increase in stroke also coincides with the introduction of combination antiretroviral drugs in the mid-1990s and increased usage of these drugs in subsequent years. Also supporting this notion is the change in the demographics over time, with older, male, and African American subjects encountered later in the study period. Each of these demographic factors could independently increase the rate of stroke alone and account for some of the observed differences. Similarly, longer exposure to HIV, even at low viral load levels, may allow for the direct effects of the virus to increase stroke risk. Second, combination antiretroviral therapy directly causes immune activation and metabolic and endothelial dysfunction that can accelerate atherosclerosis9-11 and lead to symptomatic ischemic vascular events.12,13 Third, hepatotoxicity is a known complication of combination antiretroviral drug treatment,14 and in our multivariable analyses among factors independently linked to coexistent HIV infection with stroke hospitalization, mild liver disease had by far the strongest association. It is possible that the hepato-renal dysfunction may contribute to the metabolic syndrome leading to accelerated vascular disease."
Bruce Ovbiagele, MD, MSc and Avindra Nath, MD
From the Stroke Center and Department of Neuroscience (B.O.), University of California at San Diego, San Diego; and Division of Neuroimmunology and Neurological Infections (A.N.), Department of Neurology, Johns Hopkins University, Baltimore, MD.
Address correspondence and reprint requests to Dr. Bruce Ovbiagele, Stroke Center and Department of Neuroscience, University of California at San Diego, 200 West Arbor Drive, MC 8466, San Diego, CA 92103-8466 bruce.ovibes@gmail.com
Abstract
Background: Large-scale epidemiologic data on stroke in HIV-infected persons are scarce, especially in an era of combination antiretroviral therapies, which have prolonged patient survival, but may boost stroke risk. We assessed trends in the proportion of HIV infection among patients with stroke in the United States.
Methods: Data were obtained from all states within the United States that contributed to the Nationwide Inpatient Sample. All patients admitted to hospitals between 1997 and 2006 with a primary discharge diagnosis of stroke (identified by the International Classification of Diseases, Ninth Revision procedure codes) were included. Time trends in the proportion of these patients with HIV diagnosis were computed, and independent predictors of comorbid HIV diagnosis evaluated using multivariable logistic regression.
Results: Of all (ischemic and hemorrhagic) stroke hospitalizations, patients with comorbid HIV infection constituted 0.09% in 1997 vs 0.15% in 2006 (p < 0.0001). Actual numbers of overall US stroke hospitalizations lessened 7% (998,739 to 926,997), while actual numbers of stroke hospitalizations with coexisting HIV infection rose 60% (888 to 1,425). Patients with comorbid HIV infection comprised 0.08% of ischemic strokes in 1997 vs 0.18% in 2006 (p < 0.0001), but their proportion of hemorrhagic strokes did not significantly change. Factors independently associated with higher odds of comorbid HIV diagnosis were Medicaid insurance, urban hospital type, dementia, liver disease, renal disease, and cancer.
Conclusion: Over the last decade in the United States, there has been a substantial and significant rise in patients hospitalized for stroke with coexisting HIV infection. This has important public health and socioeconomic consequences.
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GLOSSARY
ICD-= International Classification of Diseases, Ninth Revision; IC= intracerebral hemorrhage; NI= Nationwide Inpa- tient Sample; PP= positive predictive value; SA= subarachnoid hemorrhage.
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Cerebrovascular disease in HIV-infected patients is generally underrecognized, underreported, and understudied.1 Indeed, there are relatively few epidemiologic data quantifying or qualifying associations of HIV infection with stroke risk.2 Specifically, recent data on stroke trends in HIV-infected persons during a period marked by the advent of effective combination antiretroviral regimens that have reduced morbidity and mortality, but which have also been linked to increased risk of stroke, are lacking. A better understanding of the evolving occurrence of stroke in HIV-infected patients, especially on a nationwide level, could raise awareness and open up avenues for curbing this major neurologic complication of HIV.
The objective of this study was threefold. First, we aimed to assess recent time trends in the proportion of HIV infection among persons hospitalized in the United States with stroke. Second, we set out to examine how these time trends varied by index stroke type. Finally, we evaluated sociodemographic, hospital, and clinical factors independently associated with presence of HIV infection in patients hospitalized for stroke.
RESULTS
Over the study period, the weighted number of total primary stroke diagnoses in the United States generally declined, with 71,742 fewer incident strokes (7.2% relative drop) in 2006 compared to 1997 (table 1). However, total primary stroke diagnoses among persons with comorbid HIV infection generally rose (table 1), with 537 more incident strokes (60.5% relative rise) in 2006 compared to 1997 (trend for change in proportion: p <0.0001). Figure e-1 and table e-1 on the Neurology¨ Web site at www.neurology.org show that in the general HIV-negative population, stroke hospitalization rates decreased from 375 hospitalizations per 100,000 persons in 1998 to 311 hospitalizations per 100,000 persons in 2006 (p < 0.0001), a 17% rate decrease. As seen in figure e-2 and table e-1, the results in the HIV+ population were less pronounced after taking into account population size, since the observed increase in the absolute number of strokes was largely explained by a growing HIV+ US population which increased by close to 40% from 1998 to 2006. However, even after adjustment for population size, following an initial period of decline prior to 2001 there was a roughly 43% increase in the rate of stroke hospitalizations in the HIV+ US population after 2001 from 90 hospitalizations per 100,000 persons in 2001 to 129 hospitalizations per 100,000 persons in 2006 (p = 0.02).
Table 2 displays descriptive summary statistics (for simplicity, only results for 1997 and 2006 are shown) for patients hospitalized with primary stroke who had comorbid HIV infection. These results were broadly comparable across several variables. There was an approximately 6-year rise in median patient age by 2006. Of note, there were also changes of greater than 10% points across the decade in the following variables: increase in Medicare patients and decrease in privately insured patients; rise in patients encountered at urban teaching hospitals and decrease in those seen at nonurban teaching facilities; greater prevalence of hypertension, chronic pulmonary disease, and mild liver disease. The median duration of hospitalization of HIV-infected patients with stroke remained constant (4.9 vs 4.5 days).
Figure 1 and table e-2 show the percentage of coexistent HIV infection among primary stroke diagnoses stratified by type in the United States from 1997 to 2006. As shown, the proportion of ischemic strokes that occurred in patients with a comorbid HIV diagnosis more than doubled from 1997 to 2006 (trend: p < 0.0001). Conversely, the proportion of incident sub- arachnoid hemorrhage (SAH) (trend: p = 0.27) or incident intracerebral hemorrhage (ICH) (trend: p = 0.88) that occurred in patients with a comorbid HIV diagno- sis did not follow a significant linear trend across time. Results of the secondary analysis including both primary and secondary stroke diagnoses were similar to those of primary strokes alone (figure e-3): there was an increase in the proportion of HIV+ diagnoses among patients who had a diagnosis of ischemic stroke (trend: p < 0.0001), but not among patients who had SAH (trend: p = 0.56) or ICH (trend: p = 0.77). Table 3 displays results for the relation between various factors and the odds of comorbid HIV diagnosis in patients primarily hospitalized with stroke. In unadjusted analysis, increasing age, female sex, and non-Northeast hospital region were associated with significantly lesser odds of comorbid HIV diagnosis, while nonwhite race, non-Medicare insurance, nonrural hospital type, and index hemorrhagic strokes were associated with significantly greater odds of comorbid HIV diagnosis. Medical conditions associated with greater odds of comorbid HIV diagnosis were mild liver disease, moderate/severe liver disease, renal disease, and cancer.
Both multivariable models produced similar OR estimates, and were consistent with the directions of the unadjusted analysis except for a few noteworthy differences (table 3). Unlike the unadjusted analysis, multivariable model results indicated that compared to Medicare patients those with private or "other" insurance actually had lesser odds of comorbid HIV diagnosis. Another important deviation from the un- adjusted analysis was that in the multivariable analy- ses hemorrhagic strokes were associated with a decrease (not an increase) in the odds of comorbid HIV diagnosis when compared to patients with isch- emic stroke, the unadjusted result likely mainly con- founded by age, since younger patients were much more likely to have comorbid HIV diagnosis and hemorrhagic stroke (the positive association of SAH and ICH stroke types with comorbid HIV diagnosis all but disappeared with adjustment for age alone).
DISCUSSION
We found that over the last decade, there was a significant rise of approximately 67% in the proportion of patients hospitalized for stroke who had prevalent HIV infection in the United States. The rise occurred in the setting of a 7% decrease in actual numbers of overall stroke hospitalizations in 2006 (vs 1997), and a 60% increase in actual numbers of stroke hospitalizations with coexisting HIV infection in 2006 (vs 1997), indicating that the boost in proportion of patients hospitalized for stroke with prevalent HIV infection was not driven by recently recognized reductions in stroke incidence due to traditional vascular risk factor control, but possibly by evolving circumstances unique to HIV- infected patients. Although the absolute numbers of stroke hospitalizations with HIV infection are relatively small, reflecting the fact that stroke is generally an infrequent manifestation of HIV infection, this steep rise over a short period of time may be of major public health concern. This is coupled with an increase in patients on Medicaid and a decrease in those on private insurance, which has important socioeconomic consequences.
It is noteworthy that the observed increase in patients hospitalized for stroke with coexisting HIV infection seemed compelled by a rise in ischemic stroke and not hemorrhagic stroke hospitalizations. If anything, the proportions of patients hospitalized for SAH and ICH with prevalent HIV infection were lower in 2006 compared to 1997, albeit nonsignificantly. Conversely, the proportion of patients hospitalized for ischemic stroke with comorbid HIV infection more than doubled by 2006, and it appears that the first major uptick began about midyear of 2001.
The precise reasons for the rise in patients hospitalized for stroke with coexisting HIV infection are not immediately clear and are beyond the scope of this administrative dataset to decipher. However, there are some speculations that could be made based partly on these results as well as prior knowledge. The median age for stroke in this population was the fifth decade, which is much lower than that of the non-HIV-infected population. This indicates that HIV infection or its treatment is directly related to the stroke pathophysiology in this population. HIV infection can cause stroke via several mechanisms including HIV-stimulated endothelial activation (predisposing to accelerated atherosclerosis), opportunistic infections, neoplasia, HIV-induced cardiac disease, HIV-associated cerebral vasculopathy, HIV-induced systemic vasculitis, prothrombosis, and metabolic derangements.4-8 So for instance, the observed increase in several metabolic factors over time may have predisposed these patients to greater risk for developing strokes. It is also possible that recently there has been greatly increased action by the virus in facilitating these mechanisms to the extent that ischemic stroke incidence in particular is much higher, but this would seem unlikely without any supportive evidence.
A more plausible explanation could be that these trends reflect consequences of broad use of combination antiretroviral therapies in HIV-infected patients. First, combination antiretroviral therapy increases life expectancy and as such inadvertently boosts the risk of ischemic stroke, a condition that is highly age-correlated and occurs with greater length of time exposure to conventional vascular risk factors.1 In fact, the increase in stroke also coincides with the introduction of combination antiretroviral drugs in the mid-1990s and increased usage of these drugs in subsequent years. Also supporting this notion is the change in the demographics over time, with older, male, and African American subjects encountered later in the study period. Each of these demographic factors could independently increase the rate of stroke alone and account for some of the observed differences. Similarly, longer exposure to HIV, even at low viral load levels, may allow for the direct effects of the virus to increase stroke risk. Second, combination antiretroviral therapy directly causes immune activation and metabolic and endothelial dysfunction that can accelerate atherosclerosis9-11 and lead to symptomatic ischemic vascular events.12,13 Third, hepatotoxicity is a known complication of combination antiretroviral drug treatment,14 and in our multivariable analyses among factors independently linked to coexistent HIV infection with stroke hospitalization, mild liver disease had by far the strongest association. It is possible that the hepato-renal dysfunction may contribute to the metabolic syndrome leading to accelerated vascular disease.
This study has limitations. We cannot exclude possible inaccurate reporting of ICD codes, we lacked information on the rate of nonhospital strokes in the country, and did not count stroke as a secondary hospital diagnosis. Furthermore, we were unable to evaluate use or duration of antiretroviral therapy prior to the index stroke hospitalization, or at dis- charge. The study benefited from its nationwide scope and clinician-diagnosed incidence data.
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