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Pairwise Comparison of genotypic tropism prediction between one reference center and 10 European laboratories
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Rolf Kaiser
www.genfor.org
http://coreceptor.bioinf.mpi-inf.mpg.de/index.php
In the abstract the authors say "genotypic tropism testing using proviral DNA shows a higher rate of CXCR4 detection as compared with genotypic tropism testing using viral RNA. In combination with a high FPR cutoff of 20% reasonable safety for the patients can be realized. In our opinion, genotypic tropism testing from proviral DNA provides an excellent tool for switching strategies at a viral load below detection limit."
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