S/GSK1349572 Demonstrates Significantly Slower Dissociation Rates than Raltegravir when Comparing Wild Type and Raltegravir Resistant Integrase Protein

Conference Reports for NATAP

International HIV and Hepatitis Drug Resistance Workshop
June 8-12, 2010,
Dubrovnik Croatia


S/GSK1349572 Demonstrates Significantly Slower Dissociation Rates than Raltegravir when Comparing Wild Type and Raltegravir Resistant Integrase Protein

	Reported by Jules Levin International HIV & Hepatitis Virus Drug Resistance Workshop 8-12 June 2010, Dubrovnik, Croatia Kendra Hightower, Ruolan Wang, Mark Underwood GlaxoSmithKline Felix Deanda, et al. Structural models of HIV-1 integrase and DNA in complex with S/GSK1349572, Raltegravir or Elvitegravir: structure-based rationale for INI resistance profiles.