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Preclinical Characterization of a Series of Highly Potent Achiral Phosphorodiamidate Nucleotide Analogue Inhibitors of Hepatitis C Polymerase
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Reported by Jules Levin
AASLD Nov 5-8 2011 SF
EASL: A Study of the Safety and Pharmacokinetics of Single Ascending Oral Doses of INX-08189, a Nucleotide Polymerase Inhibitor, in Healthy Subjects - (04/11/11)
J. Vernachio1, B. Bleiman1, K. D. Bryant1, S. Chamberlain1, B. Ganguly1, E. Gorovits1, A. Hall1, G. Henson1, D. Hunley1, J. Hutchins1, A. Kolykhalov1,
J. Muhammad1, A. Obikhod1, N. Raja1, C. R. Walters1, J. Wang1, K. Williams1, H. Zhao1, C. McGuigan2, K. Madela2, M. Aljarah2,C. Bourdin2, S. Jones2and J. Patti1
1Inhibitex, Inc., Alpharetta, Georgia, USA, 2 Welsh School of Pharmacy, Cardiff University, Cardiff, UK
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