 |
|
|
| |
Low CD4 Count on Effective HAART is Associated With Immunologic and Vascular Dysfunction
|
| |
| |
Reported by Jules Levin
CROI 2011 March 2 Boston
Hiroyu Hatano1, Priscilla Hsue1, Peter Hunt1, Jeffrey N. Martin1, Tzong-Hae Lee2, Elizabeth Sinclair1, Michael P. Busch1,2, and Steven G. Deeks1
1University of California, San Francisco; 2Blood Systems Research Institute, San Francisco, CA
Background
Emerging data from a number of independent cohorts indicate that the current CD4+ T cell count on suppressive HAART is a strong predictor of subsequent non-AIDS morbidity and mortality. This effect has been most consistently seen among treated individuals with a CD4+ T cell count <350 cells/mm3. We therefore undertook a comprehensive immunologic and virologic assessment of treated patients who had undetectable viral loads and either a "low" (<350 cells/mm3) or a "high" (≥350 cells/mm3) current CD4+ T cell count.
|
| |
|
|
|
|
|
