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Chronic hepatitis B patients with advanced fibrosis/compensated cirrhosis can benefit from peginterferon
alfa-2a (40KD): improved or comparable response rates versus mild fibrosis in the phase III studies
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Reported by Jules Levin
Presented at the 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), November 9-13, 2012, Boston, USA
T. Piratvisuth,1 P. Marcellin,2 E. Gane,3 J. Jia,4 F. Bonino,5 G. Germanidis,6 S. Woon Paik,7 C. Yurdaydin,8 V. Rothe,9 L. Regep,10 C. Wat,11 K-X. Luo,12 R. Jin,13 Y-F. Liaw14
1NKC Institute of Gastroenterology and Hepatology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand; 2Service d'Hépatologie and INSERM CRB3/U773, University Paris-Diderot, Clichy, France; 3New Zealand Liver Transplant Unit, University of Auckland, Auckland, New Zealand;
4Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; 5Digestive and Liver Disease Division and General Medicine 2 Unit, University Hospital of Pisa, Pisa, Italy; 6First Department of Internal Medicine, AHEPA Hospital of the Aristotle University Medical School, Thessaloniki, Greece;
7Division of Gastroenterology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea; 8Department of Gastroenterology, University of Ankara Medical School, Ankara, Turkey; 9IST GmbH, Mannheim, Germany; 10F. Hoffmann-La Roche, Basel, Switzerland; 11Roche Products Limited, Welwyn Garden City, United Kingdom;
12Department of Infectious Diseases, Nanfang Hospital, Guangzhou, China; 13Beijing Friendship Hospital, Capital Medical University, Beijing, China; 14Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Author disclosures: T. Piratvisuth: advisory board member for Roche, Novartis and Merck; speaker for Roche, Novartis, Merck, Glaxo SmithKline and Bristol-Myers Squibb; received grants from Roche, Novartis and Bristol-Myers Squibb. P. Marcellin: received grants from Roche, Gilead Sciences, Janssen/Tibotec and Merck; speaker and/or expert for Roche, Gilead Sciences, Bristol-Myers Squibb, Vertex, Novartis, Janssen/Tibotec, Merck and Abbott; investigator for Roche, Gilead Sciences, Bristol-Myers Squibb, Vertex, Novartis, Janssen/Tibotec, Merck, Boehringer Ingelheim, Abbott and Pfizer. E. Gane: advisory board member for Roche, Gilead, Novartis, Abbott and Janssen/Tibotec; speaker for symposia sponsored by Roche, Gilead and Novartis. J. Jia: received honoraria for giving lectures and attending consultation meetings for Bristol-Myers Squibb, Merck, Novartis and Roche. C. Yurdaydin: advisory board member for Merck and Gilead Sciences; speaker for Roche, Gilead Sciences, Bristol-Myers Squibb and Merck. L. Regep: F. Hoffmann-La Roche employment. C. Wat: Roche Products Ltd employment. Y-F. Liaw: global advisory board member for Roche, Bristol-Myers Squibb, Novartis and Gilead Sciences. F. Bonino, G. Germanidis, SW. Paik, V. Rothe, K-X. Luo and R. Jin have no disclosures.
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