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Relationship between Precore / Core Promoter Mutants, HBeAg levels and Serological Response in HBeAg-Positive Chronic Hepatitis B Patients treated with Nucleos(t)ide Analogues 2
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Reported by Jules Levin
EASL 2012
Roeland Zoutendijk, Milan J. Sonneveld, Jurrien Reijnders, Anneke J. Van Vuuren,
Bettina E. Hansen, Andre Boonstra and Harry L.A. Janssen
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
EASL: Relationship between precore / core promoter mutants, HBeAg levels and serological response in HBeAg-positive chronic hepatitis B treated with nucleos(t)ide analogues - (05/07/12)
Conclusions: Presence of PC/BCP mutants before NUC therapy was associated with lower levels of HBeAg and a higher probability of HBeAg seroconversion. However, presence of PC/BCP mutants also predisposed to persistent replication or HBeAg relapse after HBeAg seroconversion.
EASL: Presence of precore and core promoter mutants limits the probability of response to peginterferon in hepatitis B e antigen-positive chronic hepatitis B - (05/07/12)
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