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THE RISK FOR HCC AMONG PATIENTS WITH CHRONIC HCV INFECTION AND ADVANCED HEPATIC FIBROSIS FOLLOWING SVR
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Reported by Jules Levin
AASLD Nov 1-4 2013 Wash DC
From Jules: By 2030 app. 45% of patients with chronic HCV infection is expected to have cirrhosis......This study examined the risk for developing HCC (liver cancer) for patients who achieved SVR.........study reports: 'Patients with HCV-induced cirrhosis who attain SVR remain at risk for HCC'.....the HCC rate after 8 years followup was 8.5%......after 7=8 yrs followup the risk for developing HCC for patients >60 yrs old was 12.2%, for those 45-60 the rate was 9.7% & for patients <45 yrs old the rate was 2.6% highlighting the increased risk when older......platelet count was associated with disease severity in univariate analysis and marginally in multivariate analysis while AST/ALT ratio was marginally associated in univariate analysis (see slide below)......Among these patients, the risk of HCC was associated with:
- Age (patients 45-60 & >60 had 8-9 times increased risk for developing HCC compared to patients <45)
- Severity of liver disease
- Diabetes mellitus'
........."recommend continued HCC surveillance among patients with cirrhosis and SVR"
A.J. van der Meer1, J.J. Feld2, H. Hofer3, P.L. Almasio4, V. Calvaruso4, C.M. Fernández-Rodríguez5, S. Aleman6,7, N. Ganne8, R. D'Ambrosio9, S. Pol10, M. Trapero-Marugan11, R. Moreno-Otero11, V. Mallet10, R. Hultcrantz6, O. Weiland7, K. Rutter3, V. Di Marco4, S. Alonso5, S. Bruno12, M. Colombo9, R.J. de Knegt1, B.J. Veldt1, B.E. Hansen1, H.L.A. Janssen1,2
1 Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
2 Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
3 Medical University of Vienna, Vienna, Austria
4 University of Palermo, Palermo, Italy
5 University Hospital Fundacion Alcorcon, Madrid, Spain
6 Karolinska University Hospital, Stockholm, Sweden
7 Karolinska Institutet, Stockholm, Sweden
8 AP-HP Jean Verdier Hospital, University Paris 13, Bondy, France
9 Universita degli Studi di Milano, Milan, Italy
10 Universite Paris Descartes, Inserm U1016, Paris, France
11 University Hospital La Princesa & Princesa Research Institute, Autonomous University of Madrid, Madrid, Spain
12 Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy
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