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UNMC Part Of International Hepatitis C Registry
To Improve Treatment (HCV-TARGET)
Jan 09, 2014
The University of Nebraska Medical Center in Omaha is involved in an international registry that's evaluating new treatments for hepatitis C, a disease that threatens many baby boomers.
Many of the estimated three million people in the U.S. who have the virus, an overwhelming majority being baby boomers, don't know they are infected. Hepatitis C is responsible for 12,000 deaths annually in the U.S, according to the Centers for Disease Control and Prevention.
UNMC, a regional referral center for hepatitis C, is part of the Hepatitis C Therapeutic Registry and Research Network, or HCV-TARGET. The network will track thousands of patients over the next five years to monitor the effectiveness and safety of new drugs to determine which ones are most effective and can cure the disease most quickly with the fewest side effects.
The project is important because in the next few years, several new, more superior medications will be approved for hepatitis C therapy, said Dr. Mark Mailliard, chief of the UNMC Division of Gastroenterology and Hepatology. "With the availability of new drugs, we will be able to capture a wealth of information that's critical to determining which drugs are best and for which patients," said Dr. Mailliard. "This is a great example of translational research at its best, taking the latest research discoveries to patients."
The network, which receives support from pharmaceutical companies, is made up of university and community physicians at 103 sites in 31 states, Puerto Rico, Canada and Europe, in partnership with the U.S. Food and Drug Administration. It's estimated that about two percent of the world's population is infected with hepatitis C. If left untreated, the virus causes liver damage, cancer or cirrhosis. Fatigue may be the only symptom of the disease.
Anyone being treated for the virus using newer medications is eligible to participate in the registry. Dr. Mailliard said most of the current drugs used to treat hepatitis C, typically interferon and ribavirin, have many side effects and require self-administered injections. But he said over the next three years, the use of interferon will slowly go away because of new drugs that will be more effective with much less side effects.
"We're really very excited about the registry. So far we've provided outcome data on more than 120 patients of the 2,000 studied so far." Our treatment success rate was significantly better than the average rate."
People born between 1945 and 1965 are encouraged to get tested since many don't recognize they are at risk for the disease. A simple blood test can diagnose the disease.
"Not only will treatment reduce the chance for liver failure and liver cancer, the diagnosis reminds patients of the danger of alcohol use and obesity, which increase the risk of getting cirrhosis and cancer," said Dr. Mailliard.
The hepatitis C virus is usually is spread through contact with an infected person's blood, mostly by sharing needles, syringes or other equipment to inject drugs. Before 1992, when widespread screening of the blood supply began in the U.S., hepatitis C also was commonly spread through blood transfusions.
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