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Hand osteoarthritis, a joint disorder frequent and more severe HIV-1 patients : METAFIB OA Study
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- from jules: HIV+ experience more severe and earlier onset & is associated with metabolic syndrome
Reported by Jules Levin
CROI 2014 March 3-6 Boston, MA
Anne-Tomi1 Jeremie Sellam1,2 Laurence Tomi , Sellam , , Karine Lacombe2,3, Manuela Sebire3, Caroline Rey-Jouvin1,2,
Anne Miquel4, Emmanuel Maheu1, Francis Berenbaum1,2, Pierre-Marie Girard2,3, Jean-Luc Meynard3
1AP-HP, Hopital Saint-Antoine, Rheumatology Unit, Paris, FRANCE, 2Universite Pierre et Marie Curie, Paris, FRANCE, 3AP-HP, Hopital Saint-Antoine, Infectious Diseases Unit, Paris, FRANCE, 4AP-HP, Hopital Saint-Antoine, Radiology Unit, Paris, FRANCE.
Corresponding author : jean-luc.meynard@sat.aphp.fr
Conclusion
HIV-1 patients more frequently exhibit HOA than the general population of the same age and are at-risk of more severe HOA, particularly in case of MetS. HIV and OA may be associated through the accelerated aeging and metabolic syndrome [MetS] frequently observed during HIV infection Thus the role of low-grade systemic inflammation may explain such a link between the 2 diseases.
"Conclusions: HIV-1 patients more frequently exhibit HOA than the general population of the same age and are at-risk of more severe HOA, particularly in case of MetS......Prevalence of HOA was higher in the HIV-infected population than in the general population in the same age group.......RZ was also more frequently observed in MetS+ patients (26.1 vs 14.1%, p=0.01). MetS was associated with more severe HOA:.....Concerning the severity of HOA, mean (SD) sum of KL score was higher in MetS+ (6.8, 0.9) than MetS- patients (3.7, 0.5), p=0.002. Results were similar for the number of affected joints [MetS+: 3 2 (0 4) vs MetS : 1 8 (0 2); p=0 002]"
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Background - Osteoarthritis (OA) is one of the most frequent joint disorders, causing chronic pain and functional disability. Among OA, hand OA is one of the most frequent localizations. Accelerated aging and metabolic syndrome (MetS) are common among HIV-infected patients, both of which are risk factors for OA. Moreover, OA has never been studied in the setting of HIV infection.
Objectives - 1) To assess the prevalence of hand OA (HOA) in HIV-1 patients in order to determine whether HOA is more frequent in this population compared to the general population;
2) To identify risk factors of HOA, with a special emphasis on MetS and its separate components, in the context of HIV
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