![](images/null.gif) |
![](images/null.gif) |
![](images/null.gif) |
|
Dual-Combination Therapy (NASH) Directed Against Lysyl Oxidase-Like-2 and Apoptosis Signal-Regulating Kinase 1 Potently Inhibits Fibrosis and Portal Hypertension in a New Mouse Model of PSC-Like Liver Disease/NASH
|
|
|
Reported by Jules Levin
AASLD 2015 Nov 13-17 San Francisco
Naoki Ikenaga,1 Susan Liu,1 Kahini Vaid,1 Zhen-Wei Peng,1 Andrew Greenstein,2 Dorothy French,2 Victoria Smith,2 Yury Popov1
1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 2Gilead Sciences, Inc., Foster City, CA
GS-4997, an apoptosis signal-regulating kinase (ASK1) inhibitor, is currently being evaluated in a Phase 2 study of patients with NASH and moderate to severe liver fibrosis. Simtuzumab, an anti-lysyl oxidase-like-2 (LOXL2) antibody, is being evaluated for the treatment of NASH and PSC in ongoing Phase 2b trials.
![AASLD1.gif](../images/122215/122215-4/AASLD1.gif)
![AASLD2.gif](../images/122215/122215-4/AASLD2.gif)
![AASLD3.gif](../images/122215/122215-4/AASLD3.gif)
![AASLD4.gif](../images/122215/122215-4/AASLD4.gif)
![AASLD5.gif](../images/122215/122215-4/AASLD5.gif)
![AASLD6.gif](../images/122215/122215-4/AASLD6.gif)
|
|
|
![](images/null.gif) |
![](images/null.gif) |
|
|