![](images/null.gif) |
![](images/null.gif) |
![](images/null.gif) |
|
Resistance Analysis of Virologic Failures in Hepatitis C Genotype 1-Infected Patients Treated With Grazoprevir + Elbasvir ± Ribavirin: the C-WORTHY Study
|
|
|
Reported by Jules Levin EASL 2015 April 22-26 Vienna Austria
Stuart Black1; Irene Pak1; Paul Ingravallo1; Pat McMonagle1; Robert Chase1; Melissa Shaughnessy1; Peggy Hwang1; Barbara Haber1; P. Richard Harrigan2; Chanson Brumme2; Daria Hazuda1; Anita Y.M. Howe1
1Infectious Diseases, Merck & Co., Inc., Kenilworth, NJ, USA; 2BC Centre for Excellence in HIV/AIDS, University of British Columbia, Vancouver, Canada
MK8408 is a 2nd generation picomolar pangenotypic MS5A inhibitor in development by Merck, and as previously mentioned acquired 2 two nucleotide prodrugs/nuk polymerase inhibitors from Idenix (IDX21437 and IDX21459):
A Phase 1 Study to Evaluate the Interaction of HCV NS5B Inhibitor MK-3682 With HCV NS3/4A Protease Inhibitor MK-5172 and HCV NS5A Inhibitor MK-8408 in Healthy Subjects - (04/23/15)
MK-8408, a Potent and Selective NS5A Inhibitor With a High Genetic Barrier to Resistance and Activity Against HCV Genotypes 1-6......http://www.natap.org/2014/AASLD/AASLD_40.htm
The Combination of Grazoprevir (MK-5172), an NS3 Inhibitor, and MK-8408, an NS5A Inhibitor, Presents a High Genetic Barrier to Resistance in HCV Genotypes 1a and 3a......http://www.natap.org/2014/AASLD/AASLD_56.htm
![EASL1.gif](../images/050415/050415-6/EASL1.gif)
![EASL2.gif](../images/050415/050415-6/EASL2.gif)
![EASL3.gif](../images/050415/050415-6/EASL3.gif)
![EASL4.gif](../images/050415/050415-6/EASL4.gif)
![EASL5.gif](../images/050415/050415-6/EASL5.gif)
![EASL6.gif](../images/050415/050415-6/EASL6.gif)
![EASL7.gif](../images/050415/050415-6/EASL7.gif)
![EASL8.gif](../images/050415/050415-6/EASL8.gif)
![EASL9.gif](../images/050415/050415-6/EASL9.gif)
![EASL10.gif](../images/050415/050415-6/EASL10.gif)
![EASL11.gif](../images/050415/050415-6/EASL11.gif)
![EASL12.gif](../images/050415/050415-6/EASL12.gif)
|
|
|
![](images/null.gif) |
![](images/null.gif) |
|
|