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Gilead at EASL 2015
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EASL: Gilead Announces Data for Investigational, All-Oral, Pan-Genotypic Three-Drug Regimen of Sofosbuvir, GS-5816 and GS-9857 for Chronic Hepatitis C - (04/24/15)
EASL: Gilead's Harvoni and Sovaldi Demonstrate Efficacy and Safety among Chronic Hepatitis C Patients with Advanced Liver Disease - (04/24/15)
GS-5816 + Sofosbuvir +/- Rbv Efficacy......
EASL: Resistance Analysis of Treatment-Experienced Genotype 1 and 3 HCV-Infected Patients Treated With Sofosbuvir in Combination With GS-5816 ± Ribavirin for 12 Weeks - (05/04/15)
Phase 3 study - Gt1-6 EASL: The ASTRAL Studies: Evaluation of SOF/GS-5816 Single-Tablet Regimen for the Treatment of Genotype 1-6 HCV Infection - (05/04/15)
EASL: A Single-Tablet Regimen of Ledipasvir/Sofosbuvir for 12 Weeks in HCV Genotype 1- or 4-Infected Patients With HIV-1 Coinfection: the Phase 3 ION-4 Study - (04/28/15)
EASL: Ledipasvir/Sofosbuvir for the Treatment of Patients With Chronic Genotype 4 or 5 HCV Infection - (04/29/15)
EASL: Retreatment of Patients Who Failed 8 or 12 Weeks of Ledipasvir/Sofosbuvir-Based Regimens With Ledipasvir/Sofosbuvir for 24 Weeks - (04/24/15)
EASL: Prevalence of Pretreatment NS5A and NS5B Resistance-Associated Variants and Genetic Variation Within HCV Subtypes Across Different Countries/Gilead-Study - (04/30/15)
EASL: The Prevalence and the Effect of HCV NS5A Resistance-Associated Variants in Patients With Compensated Cirrhosis Treated With Ledipasvir/Sofosbuvir ± RBV - (04/29/15)
EASL: Long-Term Persistence of HCV NS5A Variants After Treatment With NS5A Inhibitor Ledipasvir - (04/29/15)
EASL: HIGH EFFICACY OF RETREATMENT WITH LEDPASVIR AND SOFOSBUVIR IN HCV PATIENTS WHO FAILED INITIAL SHORT COURSE THERAPY WITH COMBINATION DAA REGIMENS (NIH SYNERGY TRIAL) - (04/28/15)
EASL: Sofosbuvir Plus Peg-IFN/RBV for 12 Weeks vs Sofosbuvir/RBV for 16 or 24 Weeks in Genotype 3 HCV-Infected Patients and Treatment-Experienced Cirrhotic Patients With Genotype 2 HCV: The BOSON Study - (04/27/15)
EASL: HCV Reinfection in Phase 3 Studies of Sofosbuvir - (04/29/15)
GS-9857 Pangenotypic Protease Inhibitor + SOF/GS5816 for 6/8 Weeks.....
EASL: SAFETY AND EFFICACY OF SHORT-DURATION TREATMENT WITH GS-9857 COMBINED WITH SOFOSBUVIR/GS-5816 IN TREATMENT-NAIVE AND DAA-EXPERIENCED GENOTYPE 1 PATIENTS WITH AND WITHOUT CIRRHOSIS - (04/23/15)
EASL: Gilead Announces Data for Investigational, All-Oral, Pan-Genotypic Three-Drug Regimen of Sofosbuvir, GS-5816 and GS-9857 for Chronic Hepatitis C - (04/24/15)
EASL: Evaluation of the Pangenotypic HCV NS3/4A Protease Inhibitor GS-9857 in Healthy Volunteers - (04/29/15)
EASL: Preclinical Profile of the Pangenotypic HCV NS3/4A Protease Inhibitor GS-9857 - (04/29/15)
EASL: 100% SVR12 With Ledipasvir/Sofosbuvir ± Ribavirin for 12 Weeks in Japanese Patients With Chronic Genotype 1 Hepatitis C Virus Who Previously Failed Protease Inhibitor + Pegylated Interferon-a + Ribavirin Therapy - (04/31/15)
EASL: 98% SVR12 in Korean and Taiwanese Patients With Chronic Genotype 2 HCV Infection Receiving 12 Weeks of Sofosbuvir Plus Ribavirin: Results From an International, Multicenter Phase 3 Study - (04/31/15)
EASL: PREDICTORS OF SUSTAINED VIRAL RESPONSE TO 4-6 WEEK DURATION THERAPY WITH LEDIPASVIR + SOFOSBUVIR + GS-9451 +/- GS-9669 IN EARLY AND ADVANCED FIBROSIS (NIH/UMD SYNERGY TRIAL) - (04/28/15)
EASL: Real-world effectiveness of Ledipasvir/Sofosbuvir 8 weeks chronic HCV treatment - (04/28/15)
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Harvoni Post-Transplant
EASL: Ledipasvir/Sofosbuvir With Ribavirin for the Treatment of Fibrosing Cholestatic Hepatitis C After Liver Transplantation - (05/04/15)
EASL: Ledipasvir/Sofosbuvir With Ribavirin is Safe and Efficacious in Decompensated and Post-Liver Transplantation Patients With HCV Infection: Preliminary Results of the SOLAR-2 Trial - (04/24/15)
EASL: Ledipasvir/Sofosbuvir With Ribavirin Is Safe in >600 Decompensated and Post-Liver Transplantation Patients With HCV Infection: An Integrated Safety Analysis of the SOLAR-1 and SOLAR-2 Trials - (04/29/15)
EASL: Early Viral Kinetics in Patients With Varying Degrees of Fibrosis and Cirrhosis in the SOLAR-1 Trial - (05/04/15)
EASL: All Oral HCV Therapy is Safe and Effective in Patients with Decompensated Cirrhosis: Report from HCV-TARGET - (04/23/15)
EASL: Time Course of Hepatic Improvement using the HepQuant® (HQ)-SHUNT Function Test during and after Treatment with Ledipasvir/Sofosbuvir in Liver Transplant Recipients with Allograft Fibrosis or Cirrhosis and Patients with Decompensated Cirrhosis who have not undergone Transplantation - (04/29/15)
EASL: Effect of Long-Term Viral Suppression With Sofosbuvir + Ribavirin on Hepatic Venous Pressure Gradient in HCV-Infected Patients With Cirrhosis and Portal Hypertension - (04/29/15)
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HBV
EASL: EFFICACY OF TENOFOVIR DISOPROXIL FUMARATE TO PREVENT VERTICAL TRANSMISSION IN MOTHERS WITH LAMIVUDINE-RESISTANT HBV - (04/29/15)
EASL: HCC Risk Scores: Application of the CU-HCC, GAG-HCC, and PAGE-B Scores to Chronic Hepatitis B Patients Treated With Tenofovir Disoproxil Fumarate (TDF) - (05/08/15)
EASL: Add-on Peginterferon Alfa-2a significantly reduces HBsAg levels in HBeAg-negative, genotype D chronic hepatitis B patients fully suppressed on nucleot(s)ide analogue treatment The HERMES Study - (05/04/15)
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Ledipasvir-sofosbuvir with or without ribavirin to treat patients with HCV genotype 1 infection and cirrhosis non-responsive to previous protease-inhibitor therapy: a randomised, double-blind, phase 2 trial (SIRIUS) - (04/08/15)
Long-term effect of HCV eradication in patients with mixed cryoglobulinemia: A prospective, controlled, open-label, cohort study - SVR - majority of patients symptoms persistently disappeared - (04/15/15)
Long-term follow-up of successful hepatitis C virus therapy: waning immune responses and disappearance of liver disease are consistent with cure - HCV traces in PBMC of 3/54 SVRs disappear after 9 yrs - (04/15/15) .......
In conclusion, residual HCV RNA can be detected up to 9 years after SVR in a minority of the patients. This low-level HCV RNA may sustain HCV-specific immune responses but does not cause detectable liver disease. Taken together, our data indicate that a treatment-induced SVR corresponds to a cure and that the clinical significance of any residual trace amounts of HCV RNA seems limited."
APASL: Sofosbuvir Plus Ribavirin for the Treatment of Russian Patients With Chronic HCV Genotype 1 or 3 Infection - (04/01/15)
published - The Cost-Effectiveness of Sofosbuvir-Based Regimens for Treatment of Hepatitis C Virus Genotype 2 or 3 Infection - (05/11/15)
4 HCV Cost-Effectiveness Studies Just Published; Costs for New Cancer/Cholesterol, Diabetes Drugs - New Model to Fund Healthcare - (04/01/15)
APASL: Sofosbuvir Plus Ribavirin, an Interferon-Free Regimen, in the Treatment of Egyptian Patients With Chronic Genotype 4 HCV Infection - (03/27/15)
EASL - The International Liver Congress 2015 50th Annual Meeting of the European
Association for the Study of the Liver Vienna, Austria April 22-26
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