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HCV in MSM in NY, London, SF, MACS
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HCV Tripled Among HIV+ MSM in NYC, Earlier Death Reported by NYC ......http://www.natap.org/2013/IDSA/IDSA_35.htm
(MACS Study) Incident Hepatitis C Virus Infection in Men Who Have Sex With Men: A Prospective Cohort Analysis, 1984-2011 'HIV-infection (6-fold), unprotected receptive anal intercourse (3-fold) increase risk for HCV acquisition, low CD4, syphils' - (09/20/13)......"this study demonstrates that the HCV epidemic in both HIV-infected and -uninfected MSM has been ongoing for decades. We also demonstrate that HIV infection, especially among men with lower CD4 T-cell counts; older age; and being the receptive partner with multiple unprotected sex partners increase the risk for HCV infection in MSM." .......the rates in the HIV-infected MSMs are significantly higher. Furthermore, among HIV-infected MSM, this is the first study to report a significantly higher HCV IR in men with lower CD4 T-cell counts......This study identified URAI (unprotected receptive anal intercourse) with multiple partners as the sexual behavior carrying the greatest risk for of HCV transmission......HIV infection led to a 6- to 8-fold higher incidence of HCV after adjusting for behavioral confounders.....it seems plausible that HIV-related immunosuppression could reduce the infection threshold needed for a productive systemic infection that leads to anti-HCV production as cellular mediated immunity may clear HCV without anti-HCV production [18]. A study of women also found that HIV infection increased the risk for HCV infection, and there was also a trend toward an increased risk with CD4 count <200 cells/mm"
HCV reinfection incidence and treatment outcome among HIV-positive MSM in London....."As many as 25% of individuals treated for HCV will become reinfected within 2 years".......http://www.natap.org/2013/HCV/061713_01.htm
Acute hepatitis C infection in HIV negative men who have sex with men......in UK - 'sexual HCV transmission/risky sex & drug use behavior/low rates of screening/routine screening recommended for these risk group'.......http://www.natap.org/2014/ICAAC/ICAAC_08.htm........We are concerned for un-diagnosed HCV infection and subsequent risk of onward transmission. We suggest hepatitis C testing should form a routine part of sexual health screening in all Individuals with risk factors as described, and particularly in environments with high hepatitis C prevalence.........Risky Sex and Drug Use Common in HIV-Negative MSM With Acute HCV......http://www.natap.org/2014/ICAAC/ICAAC_13.htm
HCV Screening in HIV is Poorly Implemented, MSM don't get screened adequately, only 55% get screened again after initial screen.....Those who reported MSM or heterosexual as their risk factor for HIV transmission were less likely than IDU to ever receive surveillance HCV screening......http://www.natap.org/2014/HCV/092914_06.htm
Triple Reinfections.........
EASL: SPONTANEOUS CLEARANCE RATES INCREASE WITH HCV REINFECTION EPISODE IN HIV-POSITIVE MEN WHO HAVE SEX WITH MEN (MSM) INDEPENDENT OF HCV SUBTYPE - (06/17/15)
HIV/Hepatitis C (HCV) Co-infection among Men who have Sex with Men (MSM) in New York City (NYC), 2000-2010......http://www.natap.org/2013/IDSA/IDSA_35.htm......."There was a significant upward trend in the proportion of HCV infections reported among people with HIV who are MSM. In 2000, 7% of HCV reports among people with HIV were MSM; in 2010, 24% were MSM......The increase in the percentage of HCV reports among persons with HIV that have MSM as a risk factor indicate a need for targeted hepatitis C prevention and testing campaigns for this group"
Acute hepatitis C infection in HIV-negative men who have sex with men [in London].....low HCV screening rate - (06/15/15)
HCV in HIV+ MSM in SF:
"Epidemiology of the Viral Hepatitis-HIV Syndemic in San Francisco: A Collaborative Surveillance Approach".......http://www.natap.org/2013/HCV/122713_09.htm.......among HCV/HIV coinfected males, 35.6% were MSM but not IDUs. This high percentage of coinfected, non-injection drug-using MSM suggests that sexual activity may be a prominent mode of transmission for HCV infection among this HIV-infected male population
EASL: UNDERSTANDING AND PREVENTING THE HCV EPIDEMIC AMONG MEN WHO HAVE SEX WITH MEN IN THE UK: A MATHEMATICAL MODELLING ANALYSIS - (05/18/15)
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