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Feasibility of Intermittent PrEP Among US MSM:
Data from the Harlem Site - HPTN 067: ADAPT Study
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Reported by Jules Levin
IAS Vancouver 2015 July 19-23
Sharon Mannheimer, Yael Hirsch-Moverman, Avelino Loquere, Julie Franks, James Hughes, San-San Ou, K. Rivet Amico, Craig Hendrix, Bonnie J. Dye, Estelle Piwowar-Manning, Mark Marzinke, Vanessa Elharrar, Michael Stirratt, Robert M. Grant for HPTN 067/ADAPT Harlem Study Team
".....Daily dosing resulted in better coverage of sex acts and better adherence (66%[daily] vs 47% vs 52%[non-daily]).....Overall coverage of sex acts and PrEP adherence suboptimal......For non-daily PrEP, incomplete coverage of sex acts was mostly related to lack of post-sex dosing"......daily took more pills but overall total pills taken were not near what was supposed to be taken.....adherence to daily 65% vs non-daily 46% time-driven vs 41% event-driven.....3 HIV sero-conversions occurred - 2 Seroconversions occurred: 1 seroconversion during 6-week pre-randomization weekly DOT study phase - Occurred at Week 4 - No detectable drug at visits preceding or at seroconversion visit- 1 of 238 participants over 22.6 person-years- Incidence 4.4%;.....1 seroconversion during 24-week post-randomization self administered PrEP phase - Occurred at Week 18 (Daily arm), 12 weeks post-randomization - No detectable drug at visit preceding seroconversion - very low level of TDF was detected only in dried blood spot (not in plasma) at the seroconversion visit - 1 of 179 participants over 83.1 person years - Incidence 1.2%"
WEBCAST You Tube:
https://www.youtube.com/watch?v=N2HMGGSmqI4
IAS: PrEP, Sex, and the Paradoxes of Prevention: Qualitative data from a cohort of New York City MSM participating in HPTN 067/ADAPT [Harlem, NY, USA] - (07/27/15)
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