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Relationship between Type of Antiretroviral Therapy, Drug-Drug Interactions, and Hospitalizations -
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"Retrospective cohort study among HIV-infected patients receiving care between 2000 - 2013..... The median (interquartile range, IQR) number of comorbidities and non-HIV medications were 5 (3 - 7) and 3 (1 - 5), respectively.....Population of HIV-infected patients is aging and likely require medications to treat age-related comorbidities..........Simultaneous use of multiple medications can result in severe medical consequences due to contraindicated drug-drug interactions (XDDI)....RESULTS: Among HIV-infected patients on traditional ART regimens, prevalence of XDDIs was 9.6%.....Patients with XDDIs (25.0%) had a significantly higher probability of being hospitalized than patients without an XDDI (15.2%).....Prevalence of XDDIs varied by ART regimen type.....Presence of XDDIs was independently associated with an increased risk of being hospitalized in the first year after initiating a traditional ART regimen."
Reported by Jules Levin
ICAAC 2015 Sept 17-21 San Diego, CA
Jakeman B1; Nasiri M2; Ruth L1; Morse C2; Mahatme S3; Patel N2
1 1University of New Mexico - Truman Clinic, Albuquerque, NM; 2Albany College of Pharmacy & Health Sciences, Albany, NY; 3Stratton Veterans' Affairs Medical Center, Albany, NY
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