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Raltegravir is Associated with Greater Abdominal Fat Increases after Antiretroviral Therapy Initiation Compared to Protease Inhibitors
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Reported by Jules Levin
September 12, 2016
18th International Workshop on Co-morbidities and Adverse Drug Reactions in HIV
P Bhagwat, I Ofotokun, GA McComsey, TT Brown, C Moser,
CA Sugar, JS Currier
"Both baseline CD4+ as well as HIV-1 RNA levels appeared to be strong predictors of WC change, with higher RNA levels and lower CD4+ levels being associated with higher increases in waist circumference......When examining effect measure modification by sex, the treatment difference for change in WC for ATV/r versus RAL was significantly larger for females than for males.....For modification of treatment by race/ethnicity: We found a significantly larger difference in WC change for DRV/r versus RAL for black individuals compared to all other race/ethnicities; For black individuals – larger wc increase for raltegravir (green) compared to darunavir (red); In addition, black individuals experienced a significantly smaller increase in WC for DRV/r compared to ATV/r`"
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